Epidemiological Studies of Specified Rare and Intractable Disease
This book presents research findings from epidemiological studies investigating chronic and intractable diseases with unidentifiable causes from a clinical perspective. Each chapter provides the latest findings on specific diseases, including procedures f
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Masakazu Washio Gen Kobashi Editors
Epidemiological Studies of Specified Rare and Intractable Disease
Current Topics in Environmental Health and Preventive Medicine Series Editor Takemi Otsuki Kurashiki, Japan
Current Topics in Environmental Health and Preventive Medicine, published in partnership with the Japanese Society of Hygiene, is designed to deliver well written volumes authored by experts from around the globe, covering the prevention and environmental health related to medical, biological, molecular biological, genetic, physical, psychosocial, chemical, and other environmental factors. The series will be a valuable resource to both new and established researchers, as well as students who are seeking comprehensive information on environmental health and health promotion. More information about this series at http://www.springer.com/series/13556
Masakazu Washio • Gen Kobashi Editors
Epidemiological Studies of Specified Rare and Intractable Disease
Editors Masakazu Washio St. Mary’s College Kurume Fukuoka Japan
Gen Kobashi Dokkyo Medical University Mibu Tochigi Japan
ISSN 2364-8333 ISSN 2364-8341 (electronic) Current Topics in Environmental Health and Preventive Medicine ISBN 978-981-13-1095-9 ISBN 978-981-13-1096-6 (eBook) https://doi.org/10.1007/978-981-13-1096-6 Library of Congress Control Number: 2018951099 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
“Nanbyo” (i.e., rare intractable diseases) may be a heavy burden not only on the patients but also on their family members because these diseases have few established therapies yet, usually develop chronically, and often lead to grea
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