Studies on Alzheimer's Disease

Dr. Domenico Praticò received his M.D. from the University of Rome “La Sapienza,” School of Medicine. He is currently a Professor of Pharmacology, Microbiology and Immunology and member of the Center for Translational Medicine at Temple Universi

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Domenico Praticò Patrizia Mecocci Editors

Studies on Alzheimer's Disease

Oxidative Stress in Applied Basic Research and Clinical Practice

Editor-in-Chief Donald Armstrong

For further volumes: http://www.springer.com/series/8145

Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief

Domenico Praticò • Patrizia Mecocci Editors

Studies on Alzheimer’s Disease

Editors Domenico Praticò Department of Pharmacology Center for Translational Medicine Temple University School of Medicine Philadelphia, PA, USA

Patrizia Mecocci Department of Clinical and Experimental Medicine Institute of Gerontology and Geriatrics Ospedale S. Maria della Misericordia Perugia University of Perugia, Perugia, Italy

ISBN 978-1-62703-597-2 ISBN 978-1-62703-598-9 (eBook) DOI 10.1007/978-1-62703-598-9 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013947168 © Springer Science+Business Media New York 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer