Epigenetic Advancements in Cancer
This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in can
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enetic Advancements in Cancer
Epigenetic Advancements in Cancer
Manoj K. Mishra • Kumar S. Bishnupuri Editors
Epigenetic Advancements in Cancer
Editors Manoj K. Mishra Department of Biological Sciences Alabama State University Montgomery, AL, USA
Kumar S. Bishnupuri School of Medicine Washington University St. Louis, MO, USA
ISBN 978-3-319-24949-0 ISBN 978-3-319-24951-3 DOI 10.1007/978-3-319-24951-3
(eBook)
Library of Congress Control Number: 2016930831 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Recent biomedical advancement and discovery of unique epigenetic modifications to target different cancer types has revolutionized the cancer treatment regime. In recent years, the roles of epigenetic regulators have taken forefront in discovering the target molecules to treat cancer. According to the American Cancer Society, in 2014, approximately 1,665,540 new cancer cases and 585,720 cancer deaths were reported in the USA only, which accounts for one of every four deaths. This projection is same for coming years too. Cancer refers to a group of diseases that share a common phenotype such as uncontrollable cell growth and proliferation. During the multistep process of carcinogenesis, cells acquire a series of genetic changes that lead to unrestrained cell growth and division, inhibition of cell differentiation, and evasion of cell death. However, these genetic changes alone are not sufficient enough to explain the phenotype of cancer cells. Concepts of “epigenetics” offer a partial but crucial explanation of carcinogenesis. The initiation and progression of cancer, traditionally considered to be a result of genetic alterations, is now realized to involve epigenetic abnormalities too. Recent advancements in the rapidly evolving field of cancer epigeneti
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