Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases
This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, c
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Barbara Stefanska David J. MacEwan Editors
Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases
Methods and
in
Pharmacology
Toxicology
Series Editor Y. James Kang University of Louisville School of Medicine Prospect, Kentucky, USA
For further volumes: http://www.springer.com/series/7653
Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases Edited by
Barbara Stefanska Department of Nutrition Science, Purdue University, West Lafayette, IN, USA
David J. MacEwan Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Editors Barbara Stefanska Department of Nutrition Science Purdue University West Lafayette, IN, USA
David J. MacEwan Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool, UK
ISSN 1557-2153 ISSN 1940-6053 (electronic) Methods in Pharmacology and Toxicology ISBN 978-1-4939-6741-4 ISBN 978-1-4939-6743-8 (eBook) DOI 10.1007/978-1-4939-6743-8 Library of Congress Control Number: 2016959003 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Epigenetics refers to alterations in gene expression without changes in the underlying DNA sequence and consists of three main components: DNA methylation, histone covalent modifications, and noncoding RNA mechanisms. Aberrant epigenetic patterns have been linked to chronic inflammation in numerous studies, which consequently leads to the development of many diseases including cancer, diabetes, multiple sclerosis and other autoimmune diseases, psychiatric, and neurodegenerative disorders. Due to the inherent reversibility of epigenetic states, epigenetic modific
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