Epigenetics, Energy Balance, and Cancer
This volume of Energy Balance and Cancer provides state-of-the-art descriptions of the rapidly evolving science of epigenetics and how it may explain mechanisms by which alterations in energy balance such as obesity and physical activity may imp
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Nathan A. Berger Editor
Epigenetics, Energy Balance, and Cancer
Energy Balance and Cancer Series Editor: Nathan A. Berger Case Western Reserve University Cleveland, OH, USA
More information about this series at http://www.springer.com/series/8282
Nathan A. Berger Editor
Epigenetics, Energy Balance, and Cancer
Editor Nathan A. Berger Center for Science, Health & Society Case Western Reserve University School of Medicine Cleveland, OH, USA
ISSN 2199-2622 ISSN 2199-2630 (electronic) Energy Balance and Cancer ISBN 978-3-319-41608-3 ISBN 978-3-319-41610-6 (eBook) DOI 10.1007/978-3-319-41610-6 Library of Congress Control Number: 2016953000 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Epigenetics, Energy Balance, and Cancer: Impact of Environmentally Induced Genetic Change Without Changing the Genome Mechanistic studies of energy balance and cancer have largely focused on regulatory effects at the level of metabolic, inflammatory, and endocrine signaling cascades and growth factors, all of which are influenced by genetic interactions with the environment. While genetic effects are hereditary and are primarily determined by the base pair sequence of DNA, recent studies indicate that major effects can be determined also by epigenetic factors that modify gene expression without altering DNA base pair sequence. Thus cancer results from aberrations that occur in oncogene activation and/or tumor suppressor gene inactivation, processes frequently shown to be due to genetic alterations in DNA base pair sequence. These sequence alterations in the genome may exist in the germline where they can be associated with hereditary cancers or they may commonly arise in somatic cells due to gene mutations and/or rearrangements where they are associated with sporadic cance
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