Estimate of prevalent ischemic stroke from triglyceride glucose-body mass index in the general population
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RESEARCH ARTICLE
Open Access
Estimate of prevalent ischemic stroke from triglyceride glucose‑body mass index in the general population Zhi Du1, Liying Xing2, Min Lin3 and Yingxian Sun1*
Abstract Background: To investigate the relationship between triglyceride glucose-body mass index (TyG-BMI) and ischemic stroke. Methods: Leveraging two Chinese general population surveys, the Northeast China Rural Cardiovascular Health Study (NCRCHS, N = 11,097) and the National Stroke Screening and Intervention Program in Liaoning (NSSIPL, N = 10,862), we evaluated the relationship between TyG-BMI and ischemic stroke by a restricted cubic spline and multivariate logistic regression after adjusting age, sex, level of education, exercise regularly, current smoking, current drinking, atrial fibrillation, hypertension, coronary artery disease, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. The category-free analysis was used to determine whether TyG-BMI enhanced the capacity of estimating ischemic stroke. Results: A total of 596 and 347 subjects, respectively, from NSSIPL and NCRCHS were survivors of ischemic stroke. In NSSIPL, the relationship between TyG-BMI and ischemic stroke was linear and did not have a threshold or saturation effect according to the results of the restricted cubic spline. The regression analysis indicated that the risk of ischemic stroke increased 20% for per SD increase of TyG-BMI after multivariate adjustment [odds ratio (OR): 1.20, 95% confidence interval (CI): 1.10–1.32]. Compared with those in the lowest tertile, the risk of ischemic stroke in subjects with intermediate and high TyG-BMI was significantly higher [OR (95% CI): 1.39 (1.10–1.74); OR (95% CI) 1.72 (1.37–2.17), respectively]. Category-free analysis indicated that TyG-BMI had a remarkable improvement in the ability to estimate prevalent ischemic stroke [NRI (95% CI): 0.188 (0.105–0.270)]. These abovementioned relationships were confirmed in NCRCHS. Conclusions: The present study found the robust correlation between TyG-BMI and ischemic stroke, independently of a host of conventional risk factors. Meanwhile, our findings also suggested the potential usefulness of TyG-BMI to improve the risk stratification of ischemic stroke. Keywords: Triglyceride glucose-body mass index, Ischemic stroke, Insulin resistance, Epidemiology
*Correspondence: [email protected] 1 Department of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang 110001, Liaoning, China Full list of author information is available at the end of the article
Background As the leading cause of death and disability in most countries, stroke presents an increasing burden on the global healthcare system [1]. According to the Global Burden of Disease 2013 Study, there were approximately 25.7 million stroke survivors alive, 6.5 million stroke-related deaths and 113 million stroke-related
© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which perm
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