Estimating the attributable risk of vascular disorders in different ranges of fasting plasma glucose and assessing the e
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RESEARCH ARTICLE
Estimating the attributable risk of vascular disorders in different ranges of fasting plasma glucose and assessing the effectiveness of anti-diabetes agents on risk reduction; questioning the current diagnostic criteria Esmaeil Mohammadi 1 & Fatemeh Sadeghi Morasa 2 & Shahin Roshani 1 & Negar Rezaei 1 & Sina Azadnajafabad 1 Sahar Saeedi Moghaddam 1 & Mehrdad Azmin 1 & Maryam Karimian 2 & Nima Fattahi 1 & Kosar Jamshidi 1 & Narges Ebrahimi 1 & Mahtab Rouhifard Khalilabad 1 & Shohreh Naderimagham 1 & Bagher Larijani 2 & Farshad Farzadfar 1,2
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Received: 12 August 2020 / Accepted: 12 October 2020 # Springer Nature Switzerland AG 2020
Abstract Introduction Attributable risk of cardiovascular disorders (CVDs) and chronic kidney disease (CKD) in association with diabetes and pre-diabetes is under debate. Moreover, the role of anti-diabetes agents in risk reduction of such conditions is obscure. The purpose of this work is to define the population attributable fraction (PAF) of CVDs and CKD in different rages of plasma glucose. Method Iranian stepwise approach for surveillance of non-communicable disease risk factors (STEPs) was used to calculate PAF in four subsequent phases. Phase 0: whole population regardless of diagnosis; Phase I: in three CVD risk groups: minimal risk (FPG < 100 mg/dL), low risk (FPG 100–126 mg/dL), and high risk (FPG ≥ 126 mg/dL) groups; Phase II: three diagnostic groups: normal, pre-diabetes, and diabetes; Phase III: diabetes patients either receiving or not receiving anti-diabetes agents. Esmaeil Mohammadi, Fatemeh Sadeghi Morasa, and Shahin Roshani contributed equally to this work. Bagher Larijani and Farshad Farzadfar are co-correspondent authors of this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40200-020-00663-5) contains supplementary material, which is available to authorized users. * Bagher Larijani [email protected] * Farshad Farzadfar [email protected] Esmaeil Mohammadi [email protected] Fatemeh Sadeghi Morasa [email protected] Shahin Roshani [email protected] Negar Rezaei [email protected] Sina Azadnajafabad [email protected] Sahar Saeedi Moghaddam [email protected]
Mehrdad Azmin [email protected] Maryam Karimian [email protected] Nima Fattahi [email protected] Kosar Jamshidi [email protected] Narges Ebrahimi [email protected] Mahtab Rouhifard Khalilabad [email protected] Shohreh Naderimagham [email protected] Extended author information available on the last page of the article
J Diabetes Metab Disord
Result A total of 19,503 participants [female-to-male ratio 1.17:1] had at least one FPG measurement and were enrolled. Phase 0: PAF of young adults was lower in the general population (PAF range for CVDs 0.05 ─ 0.27 [95% CI 0.00 ─ 0.32]; CKD 0.03 ─ 0.41 [0.00 ─ 0.62]). Phase I: High-risk group comprised the largest attributable risks (0.46 ─ 0.97 [0.32 ─ 1]; 0.74 ─ 0.95 [0.58 ─ 1]) compared to low-risk (0.16 ─ 0.41 [0.04 ─
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