Evaluating the efficacy and safety of the myrtle ( Myrtus communis ) in treatment and prognosis of patients suspected to
- PDF / 528,750 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 24 Downloads / 157 Views
STUDY PROTOCOL
Open Access
Evaluating the efficacy and safety of the myrtle (Myrtus communis) in treatment and prognosis of patients suspected to novel coronavirus disease (COVID-19): study protocol for a randomized controlled trial Maryam Azimi1,2 and Fatemeh Sadat Hasheminasab3*
Abstract Background: Since December 2019, the outbreak of coronavirus pneumonia was observed in China and quickly propagate in all of the world. Nowadays, many trials are underway on this disease in which the efficacy of various therapeutic remedies including chemical or natural agents as well as different non-pharmacological methods such as acupuncture are evaluated. This study aims at investigating the effect of M. communis fruit for treatment of COVID-19 disease. Methods: We are performing an open-label randomized controlled trial on outpatients clinically suspected to COVID-19 disease in the age range of 18–65 years old with mild to moderate symptoms and without respiratory distress. Patients in both groups (M. communis and control) receive conventional therapy, but those in M. communis group get M. communis preparation in addition to conventional therapy. Intervention will continue for 5 days and the study outcomes including clinical status as well as mortality rate and adverse effects will be measured up to 14 days. Discussion: The protocol describes the design of an ongoing randomized controlled trial to establish the evidence for the usage of water extract of M. communis fruit in clinically suspected COVID-19 disease and identify any safety concerns. Trial registration: The trial has been registered at the Iranian Registry of Clinical Trials website under the code IRCT20180923041093N3 on March 28th, 2020 (https://www.irct.ir/trial/46721). The results will be disseminated through manuscript publications and presentations to scientific meetings. Keywords: COVID-19, Myrtle, Herb, Persian medicine, M. communis
Background The outbreak of the pneumonia caused by the novel coronavirus (COVID-19) was first observed in Wuhan, Hubei province, China, in December 2019 and quickly spread all over the country, and then almost all * Correspondence: [email protected]; [email protected] 3 Pharmacology Research Center, Zahedan University of Medical Sciences (ZaUMS), Zahedan, Iran Full list of author information is available at the end of the article
throughout the world, it formed a global concern as a pandemic [1, 2]. The infection caused by the novel coronavirus has a wide range from asymptomatic infectious to mild upper respiratory tract disease which may lead to severe pneumonia and even death [3, 4]. At the onset of clinical symptoms, most patients have such complaints as fever, cough, shortness of breath, muscular pain, and fatigue. Some patients also experience loss of taste and smell, headaches, or diarrhea. Patients with
© The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any mediu
Data Loading...
