Evaluation of ameliorative effect of two selected plant drugs on experimentally induced arsenic toxicity in sheep
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RESEARCH ARTICLE
Evaluation of ameliorative effect of two selected plant drugs on experimentally induced arsenic toxicity in sheep Chinmoy Maji 1 & Suman Biswas 2 & Prasanta Kumar Sarkar 3 & Pabitra Hriday Patra 4 & Samiran Bandyopadhyay 5 & Samar Sarkar 6 & Abichal Chattopadhyay 7 & Tapan Kumar Mandal 4 Received: 20 December 2019 / Accepted: 1 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Chronic arsenic poisoning is one of the serious health hazards in West Bengal, India, and Bangladesh. It occurs due to contaminated subsoil water. The aim of this study is conducted to find out the ameliorative effect of turmeric and P. foetida powder on experimentally induced arsenic toxicity in sheep. Twelve sheep were divided into four groups; groups I, II and III were orally administered with sodium arsenite at 6.6 mg/kg body weight for 133 days; groups I and II animals were treated by turmeric and P. foetida powders respectively at 500 mg/kg dose for the last 49 days; the fourth group was control. Arsenic content was estimated in faeces, urine and wool in every 15 days. Biochemical, haematological, antioxidant parameters and DNA fragmentation were also assessed. Turmeric and P. foetida powder treatment significantly (P < 0.05) increased arsenic elimination through faeces, urine and wool. Haemoglobin content and TEC were decreased in groups I, II and III; however, these were improved significantly (P < 0.05) by turmeric and P. foetida powder treatment. Increased activity of AST, ALT, blood urea nitrogen and plasma creatinine were significantly (P < 0.05) decreased in groups I and II. The reduced SOD and catalase activity were significantly (P < 0.05) restored at the end of the experiment in turmeric and P. foetida-treated groups. The test drugs are found significantly effective not only to eliminate arsenic from the body but also give protection from possible damage caused by arsenic exposure in sheep. Keywords Antioxidant . Chronic arsenic toxicity . Paederia foetida . Sheep . Sodium arsenite . Turmeric Responsible Editor: Lotfi Aleya * Prasanta Kumar Sarkar [email protected] 1
North 24 Paraganas Krishi Vigyan Kendra, Ashokenagar, 743223 West Bengal, India
2
Department of Avian Sciences, Faculty of Veterinary & Fishery Sciences, Mohanpur, Nadia, 741252 West Bengal, India
3
J. B. Roy State Ayurvedic Medical College and Hospital, West Bengal University of Health Sciences, 170-172, Raja Dinendra Street, Kolkata, West Bengal 700004, India
4
Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata, India
5
Division of Veterinary Medicine, Indian Veterinary Research Institute-Eastern Regional Campus, Kolkata, India
6
Department of Veterinary Medicine, Ethics and Jurisprudence, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata, India
7
Institute of Post Graduate Ayurvedic Education and Research, West Bengal University o
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