Evaluation of Discriminative Detection Abilities of Social Cognition Measures for the Diagnosis of the Behavioral Varian
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REVIEW
Evaluation of Discriminative Detection Abilities of Social Cognition Measures for the Diagnosis of the Behavioral Variant of Frontotemporal Dementia: a Systematic Review Alessandra Dodich 1 & Chiara Crespi 2,3 & Gaia C. Santi 4 & Stefano F. Cappa 4,5 & Chiara Cerami 3,4 Received: 10 February 2020 / Accepted: 21 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The use of social tasks in the neuropsychological assessment of the behavioral variant of frontotemporal dementia (bvFTD) is at present not required by diagnostic guidelines, despite extensive literature shows relevant social cognitive dysfunctions in such patients. In this systematic review, we explored the clinical maturity of social cognition measures in the diagnosis of bvFTD. Papers were selected according to the PRISMA guidelines by searching the PubMed and Medline databases. Only papers reporting indices of diagnostic accuracy and/or sensitivity/specificity in classifying bvFTD from controls or from other relevant diseases were considered. Quality of evidence was assessed through QUADAS-2. Among the 663 articles entered in the paper selection only 14 papers were eligible for the scope of the present review and showed an overall moderate-to-low quality. The major risk of bias was the lack of pathological confirmation. The evaluation of the accuracy of social cognition tasks in bvFTD detection compared to normal controls, as well as in the discrimination with Alzheimer’s disease and psychiatric patients, is mainly focused on emotion recognition and theory of mind. However, the use of different cognitive measures, variable task formats and the limited normative data hamper study comparability. Although literature seems to suggest that emotion recognition and ToM tasks could be the best choice to ensure a high diagnostic accuracy in clinical settings, further comparative studies are required and no recommendation concerning the use of a specific social task in bvFTD diagnosis can be currently provided. Keywords Behavioral variant of Frontotemporal dementia . Social cognition disorders . Accuracy of socio-emotional markers in the bvFTD . Cognitive marker of bvFTD . Cognitive assessment in dementia
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11065-020-09457-1) contains supplementary material, which is available to authorized users. * Chiara Cerami [email protected] 1
CeRiN, Centre for Mind/Brain Sciences-CIMeC, University of Trento, Rovereto, Italy
2
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
3
Cognitive Computational Neuroscience Research Unit, IRCCS Mondino Foundation, Pavia, Italy
4
Scuola Universitaria Superiore IUSS Pavia, Pavia, Italy
5
Dementia Research Center, IRCCS Mondino Foundation, Pavia, Italy
Social cognition is a multifaceted complex domain resulting from the sum of different cognitive sub-functions. It includes every process aimed at recognizing and interpreting informatio
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