Evaluation of oxidative status in patients with hyperthyroidism
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ORIGINAL ARTICLE
Evaluation of oxidative status in patients with hyperthyroidism Mehmet Aslan • Niyet Cosar • Hakim Celik • Nurten Aksoy • Ahmet Cumhur Dulger • Huseyin Begenik • Yasemin Usul Soyoral Mehmet Emin Kucukoglu • Sahbettin Selek
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Received: 16 January 2011 / Accepted: 7 April 2011 / Published online: 26 April 2011 Ó Springer Science+Business Media, LLC 2011
Abstract Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in this study. Serum oxidative status was determined via measurement of total antioxidant capacity (TAC) and total oxidant status (TOS) and calculation of oxidative stress index (OSI). Serum TAC levels were significantly lower in patients with hyperthyroidism than controls (P = 0.002), while serum TOS levels and OSI values were significantly higher (P = 0.008, 0.004; respectively). Serum TAC levels were correlated with TSH levels (rho = 0.223, P = 0.032), FT3 levels (rho = -0.434, P = 0.002) and FT4 levels (rho = -0.363, P = 0.003) in patients. Further, TOS levels and OSI values were correlated with TSH levels (rho = -0.245, P = 0.037; rho = -0.312, P = 0.011, respectively), FT3 levels (rho = 0.293, P = 0.017, rho = 0.505, P = 0.002, respectively), and FT4 levels (rho = 0.302, P = 0.006, rho = 0.321, P = 0.008, respectively) in patients. Duration of disease was significantly correlated with OSI values in patients (rho = 0.420, M. Aslan (&) A. C. Dulger H. Begenik Y. U. Soyoral M. E. Kucukoglu Medical Faculty, Department of Internal Medicine, Yuzuncu Yil University, Van, Turkey e-mail: [email protected] N. Cosar N. Aksoy S. Selek Medical Faculty, Department of Clinical Biochemistry, Harran University, Sanliurfa, Turkey H. Celik Medical Faculty, Department of Physiology, Gaziantep University, Sanliurfa, Turkey
P = 0.011), while no correlation with serum TAC levels and TOS levels (P [ 0.05). Oxidants are increased and antioxidants are decreased in patients with hyperthyroidism; as a result, the oxidative–antioxidative balance is shifted to the oxidative side. Increased oxidative stress may play a role in the pathogenesis of hyperthyroidism. It is believed that supplementation of antioxidant vitamins such as vitamins C and E may be helpful for these patients. Keywords Hyperthyroidism Total oxidant status Total antioxidant capacity Oxidative stress index
Introduction Thyroid hormones (thyroxine T4 and triiodothyronine T3) are involved in the regulation of numerous body functions including lipid and carbohydrate metabolism, oxygen consumption, and several physiological functions such as development, reproduction, and growth [1]. Also, thyroid hormones act on mitochondria by regulating the energy metabolism and mitochondrion which is a major source of free radicals in the cell [2]. The thyroid gland is the body’s pr
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