Evaluation of Patients Presenting with Chest Pain in the Emergency Department: Where Do Troponins Fit In?
Patients presenting to the Emergency Department with symptoms consistent with possible acute cardiac ischaemia, particularly chest pain, are one of the most common patient groups presenting to Emergency Departments in the developed world. These patients a
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Cardiac Biomarkers
Alan S. Maisel • Allan S. Jaffe Editors
Cardiac Biomarkers Case Studies and Clinical Correlations
Editors Alan S. Maisel Division of Cardiovascular Medicine University of California San Diego La Jolla, CA USA
Allan S. Jaffe Cardiology Department Mayo Clinic Rochester, MN USA
ISBN 978-3-319-42980-9 ISBN 978-3-319-42982-3 DOI 10.1007/978-3-319-42982-3
(eBook)
Library of Congress Control Number: 2016955804 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Dedicated to Dr. Burton E. Sobel, whose pioneering work on creatine kinase and tireless mentoring were instrumental in helping us understand the importance of biomarkers, and my partner in crime at Washington University where we validated the initial assay for cTnI, Dr. Jack Ladenson. Allan S. Jaffe, MD
Preface
Biomarkers now play an integral role in the treatment and management of patients with congestive heart failure and acute ischemic heart disease because of the important information the values provide. All of us in the field are terribly interested in how to optimally use these biomarkers and particularly to understand when values provide actionable information. However, extrapolating a large compendium of information to the average clinician is difficult because many do not have the underlying basic science, laboratory, and/or clinical expertise about the use of these markers. Accordingly, it seemed to us that there was a need to develop a case-based compendium of learning. For that reason, we asked our most knowledgeable colleagues to help us generate a book that hopefully comprehensively informs clinicians about how to optimally deploy the major clinically utilized biomarkers in a case-based manner. From scrutinizing the chapters, it appears we have succeeded. We hope you will
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