Identifying patients with metformin associated lactic acidosis in the emergency department
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RESEARCH ARTICLE
Identifying patients with metformin associated lactic acidosis in the emergency department I. R. F. van Berlo‑van de Laar1 · A. Gedik2 · E. van ‘t Riet3 · A. de Meijer4 · K. Taxis5 · F. G. A. Jansman1,5 Received: 7 March 2020 / Accepted: 27 May 2020 / Published online: 22 September 2020 © The Author(s) 2020
Abstract Background Metformin associated lactic acidosis (MALA) is a serious adverse event with a high mortality rate of 30–50%. Early recognition of MALA and timely starting treatment may reduce its morbidity and mortality. Objective The aim of this study was to explore clinical parameters to identify patients with MALA in patients with suspected sepsis induced lactic acidosis in the emergency department ED. Setting A retrospective single centre study was conducted at the Deventer Teaching Hospital in the Netherlands. Method Patients with lactate concentration > 4.0 mmol/l admitted at the ED between 2010 and 2017 with suspected sepsis or confirmed MALA and referred to the Intensive Care Unit were included. Baseline characteristics (pH, lactate, creatinine and CRP) of MALA patients were compared with patients with suspected sepsis induced lactic acidosis. Creatinine and lactate concentration were selected as potential relevant parameters. Main outcome measure Sensitivity and specificity of the highest tertiles of the creatinine and the lactate concentrations separately, in combination, and both combined with metformin use, were calculated. Results Thirteen MALA and 90 suspected sepsis induced lactic acidosis patients were included. Lactate (14.7 vs 5.9 mmol/l, p
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