Evaluation of the Capacity of Granulation in Surgical Wounds with Condensed Tannins in Matrices TiO 2 .
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EVALUATION OF THE CAPACITY OF GRANULATION IN SURGICAL WOUNDS WITH CONDENSED TANNINS IN MATRICES TiO2. José Albino M. Rodrìguez.1, José Rutilio M. López1, Genaro C. Gutiérrez1, Marco-Antonio G Coronel1, Enrique S. Mora2, Lilián-Aurora M Rodríguez3, Fernando M. Rodríguez4 1
Facultad de Ciencias Químicas, 2Instituto de Física, 3Facultade Ciencias Físico-Matemáticas. Benemérita Universidad Autónoma de Puebla, Av. San Claudio y 14 Sur. Col. San Manuel, C. U. Puebla, Pue., C.P. 72570. 4 Hospital de Chiautla de Tapia, 11 Norte Carretera a Ixcamilpa S/N, C.P. 74730, Puebla. ABSTRACT. The nanoencapsulation in biocompatible inorganic materials with human cell activity is a leading technology to control the process of releasing the drug in the right place. At present, the sol-gel process has emerged as a promising platform for the immobilization, stabilization and encapsulation of biological molecules such as enzymes, antibodies, microorganisms, and a variety of drugs. The matrices obtained are chemically inert, hydrophilic and easy synthesis. They have high mechanical strength, thermal stability in wide temperature ranges and absorb organic solvents so insignificant compared with other organic polymers. They are resistant to microbial attack and exhibit high biocompatibility with the body, as provided for implantation in situ in the treatment of various diseases. An additional advantage is that it provides viability encapsulated molecules, since these matrices act as reservoirs of water thus helping to maintain the biological activity of enzymes, antibodies, cells, and drugs for the moisture level required for the molecule. We used the action of the active ingredients of tepezcohuite (condensed tannins) to assess the capacity aseptic surgical wound healing than 1 cm in diameter in New Zealand white rabbits. Experimentally and statistically demonstrating the effectiveness of healing nanoreservoirs Tan/TiO2-150 the weight of tannins by 60% compared to condensed tannins as such, TiO2 and isotonic saline.
Keywords: nanoscale, biomedical, sol-gel Corresponding author: [email protected] INTRODUCTION. For 10 years, have developed alternative methods of application to improve the outcome of burn injuries as the application of gel hydroactive, occlusive hydrocolloid dressing with ionic silver hydrofiber, stretch bands, among others, however, most of them are inappropriate for presenting a very slow healing activity or by its high cost, resulting in a heavy burden on health services and patient >1, 2@. Mexico has numerous species of plants and trees used for therapeutic purposes including tepezcohuite tree, root name of the Nahuatl language that comes from the word tepezcuahuitl, meaning “tree from hill bleeding“>3, 4@. Anton et. al. prove that the fibers, starches, triterpenoids, saponins and condensed tannins, improve treatment for burns and skin regeneration. The latter, once extracted from the bark of tepezcohuite is a reddish brown powder, bitter and odorless. So that the tannins of Mimosa tenuiflora have a potent inducing fact
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