Evaluation of Hydroxyapatite as Adsorbent in the Analysis of Trace Tetracyclines in Complex Matrices
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Evaluation of Hydroxyapatite as Adsorbent in the Analysis of Trace Tetracyclines in Complex Matrices Qian Zhou 1,2 Lihua Zhu 2
&
Hong Wang 1 & Kuanzheng Zhu 1 & Cong Yao 1 & Jin Peng 1 & Yanming Chen 1 & Shengyin Zhou 1 &
Received: 14 April 2020 / Accepted: 4 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In this work, nanoporous hydroxyapatite (nano-HA) was synthesized and used as adsorbent for extraction of tetracyclines (TCs) in complex matrices. Owing to its permanent nanoscale porosity and surface functional groups on nano-HA, nano-HA has the potential to be a two-functional adsorbent to extract TCs as well as exclude macro-molecules such as protein in matrices. Therefore, we developed a facile method for the analysis of TCs in complex matrices by coupling nano-HA extraction with high-performance liquid chromatography–diode array detection. The new method gave wide linear correlations for TC concentration ranging from 0.96 to 4000 μg kg−1 with detection limits of 0.29–1.67 μg kg−1. The proposed method was successfully applied to determine TCs in pig tissue. This nano-HA extraction technique is rapid, simple, cost-effective, and environmentally friendly and has the potential to extract TCs from other bio-matrices. Keywords Hydroxyapatite . Tetracyclines . Protein . Nanoporous . High-performance liquid chromatography
Introduction Recently, most adsorbents made from natural or synthetic inorganic materials have been appealed much attention (Zhao et al. 2009 Ulibarri et al. 1995 Polat et al. 2006 Jing et al. 2002 Yildiz et al. 2000). Hydroxyapatite (Ca10(PO4)6(OH)2, HA) is one of the most biocompatible and bioactive ceramics known, with a composition similar to the mineral phase of bone and teeth (Janus et al. 2008 Schek et al. 2006). The positively charged calcium ions (so-called C-sites) and negatively charged phosphate groups (so-called P-sites) on HA surfaces Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12161-020-01858-5) contains supplementary material, which is available to authorized users. * Qian Zhou [email protected] * Lihua Zhu [email protected] 1
Hubei Research Institute of Products Quality Supervision and Inspection, Wuchang District, Wuhan 430070, People’s Republic of China
2
College of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, People’s Republic of China
render it useful as a solid matrix for the separation of anion and cation species. HA has been currently used as adsorbent in the purification of wastewater to adsorb and remove heavy metal ions, anions, and organic pollutants (phenol) (Río et al. 2006; Sandrine et al. 2007; Lin et al. 2009; Ghasemi and Sillanpăă 2015; Badillo-Almaraz et al. 2007). Río et al. qualified and quantified the simultaneous retention of Cd, Zn, and Co onto synthetic HA-powdered filters in fixed bed continuous flux experiments. HA stabilized Cd, Zn, and Co through ionic exchange reaction and surface complexation wi
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