Evaluation of Volumetric Change of Intracerebral Hemorrhage in Patients Treated with Thrombolysis for Intraventricular H
- PDF / 1,581,814 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 22 Downloads / 184 Views
ORIGINAL WORK
Evaluation of Volumetric Change of Intracerebral Hemorrhage in Patients Treated with Thrombolysis for Intraventricular Hemorrhage Franziska Staub‑Bartelt1*, Jasper Hans van Lieshout1, Thomas Beez1, Rainer Kram2, Daniel Hänggi1 and Kerim Besoglu1 © 2020 The Author(s)
Abstract Background: Intraventricular hemorrhage (IVH) is often caused by irruption of intracerebral hemorrhage (ICH) of basal ganglia or thalamus into the ventricular system. Instillation of recombinant tissue plasminogen activator (rtPA) via an external ventricular drainage (EVD) has been shown to effectively decrease IVH volumes while the impact of rtPA instillation on ICH volumes remains unclear. In this series, we analyzed volumetric changes of ICH in patients with and without intrathecal lysis therapy. Methods: Between 01/2013 and 01/2019, 36 patients with IVH caused by hemorrhage of basal ganglia, thalamus or brain stem were treated with rtPA via an EVD (Group A). Initial volumes were determined in the first available com‑ puted tomography (CT) scan, final volumes in the last CT scan before discharge. During the same period, 41 patients with ICH without relevant IVH were treated without intrathecal lysis therapy at our neurocritical care unit (Group B). Serial CT scans were evaluated separately for changes in ICH volumes for both cohorts using OsiriX DICOM viewer. The Wilcoxon signed-rank test was performed for statistical analysis in not normally distributed variables. Results: Median initial volume of ICH for treatment Group A was 6.5 ml and was reduced to 5.0 ml after first instilla‑ tion of rtPA (p
Data Loading...
