High Serum Levels of Caspase-3 and Early Mortality in Patients with Severe Spontaneous Intracerebral Hemorrhage
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ORIGINAL WORK
High Serum Levels of Caspase‑3 and Early Mortality in Patients with Severe Spontaneous Intracerebral Hemorrhage Leonardo Lorente1* , María M. Martín2, Antonia Pérez‑Cejas3, Agustín F. González‑Rivero3, Rafael Sabatel4, Luis Ramos5, Mónica Argueso6, Jordi Solé‑Violán7, Juan J. Cáceres8, Alejandro Jiménez9 and Victor García‑Marín10 © 2020 Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society
Abstract Background: Apoptotic cell death leads to secondary brain injury after spontaneous intracerebral hemorrhage (SIH). There is an association between serum caspase-3 levels and late mortality (at 6 months) in patients with SIH in basal ganglia. The new objective of this study was to determine whether there exists an association between serum caspase-3 levels and early mortality (at 30 days) in patients with SIH at different sites and not only in basal ganglia. Methods: Patients with severe supratentorial SIH (defined as Glasgow Coma Scale
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