Evidence of CV events with calcium/vitamin D not convincing
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Evidence of CV events with calcium/vitamin D not convincing A previously published meta-analysis by Dr Mark Bolland and colleagues found that calcium supplements with or without vitamin D modestly increase the risk of myocardial infarction (MI).* However, the UK MHRA reports that a re-analysis of the data does not provide convincing evidence of any increased risk of cardiovascular (CV) events. Dr Bolland et al. re-analysed data from The Women’s Health Initiative Calcium/Vitamin D Supplementation (WHI CaD) study and conducted a further metaanalysis.** This re-analysis showed that, among women not self-medicating with calcium supplements at baseline, calcium + vitamin D slightly increased the risk of clinical MI, but this finding was of borderline significance. The MHRA notes that all-cause mortality was not increased in this patient group. Furthermore, compared with placebo, all-cause mortality was significantly reduced in women who self-medicated with calcium supplements at baseline and were randomised to calcium + vitamin D. The new metaanalysis found a lower, more precise risk for MI and stroke associated with calcium + vitamin D (relative risk 1.16; 95% CI 1.02, 1.32; p = 0.02), but there was no increased risk of all-cause mortality. The re-analysis and new meta-analysis were reviewed by the Commission on Human Medicines (CHM), and concern was expressed over methodology and data interpretation. * see Reactions 1313 p1; 801140713 ** see Reactions 1350 p7; 803053715 MHRA. Calcium and vitamin D: studies of cardiovascular risk do not support 801085492 prescribing changes. Drug Safety Update 5: H1, No. 3, Oct 2011
0114-9954/10/1374-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 22 Oct 2011 No. 1374
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