Ex-vivo quantification of ovine pia arachnoid complex biomechanical properties under uniaxial tension
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luids and Barriers of the CNS Open Access
RESEARCH
Ex‑vivo quantification of ovine pia arachnoid complex biomechanical properties under uniaxial tension Gabryel Conley Natividad1, Sophia K. Theodossiou1, Nathan R. Schiele1, Gordon K. Murdoch2, Alkiviadis Tsamis3, Bertrand Tanner4, Gabriel Potirniche5, Martin Mortazavi6, David A. Vorp7 and Bryn A. Martin1,8*
Abstract Background: The pia arachnoid complex (PAC) is a cerebrospinal fluid-filled tissue conglomerate that surrounds the brain and spinal cord. Pia mater adheres directly to the surface of the brain while the arachnoid mater adheres to the deep surface of the dura mater. Collagen fibers, known as subarachnoid trabeculae (SAT) fibers, and microvascular structure lie intermediately to the pia and arachnoid meninges. Due to its structural role, alterations to the biomechanical properties of the PAC may change surface stress loading in traumatic brain injury (TBI) caused by sub-concussive hits. The aim of this study was to quantify the mechanical and morphological properties of ovine PAC. Methods: Ovine brain samples (n = 10) were removed from the skull and tissue was harvested within 30 min post-mortem. To access the PAC, ovine skulls were split medially from the occipital region down the nasal bone on the superior and inferior aspects of the skull. A template was used to remove arachnoid samples from the left and right sides of the frontal and occipital regions of the brain. 10 ex-vivo samples were tested with uniaxial tension at 2 mm s−1, average strain rate of 0.59 s−1, until failure at
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