Examination of retinal vascular density changes via optical coherence tomography angiography in patients with glaucoma
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ORIGINAL PAPER
Examination of retinal vascular density changes via optical coherence tomography angiography in patients with glaucoma Berire S¸ eyma Durmus¸ Ece
. Murat Sinan Sarıcaog˘lu
Received: 19 March 2020 / Accepted: 17 October 2020 Ó Springer Nature B.V. 2020
Abstract Purpose The aim of this study was to investigate the changes in vessel density (VD) in glaucoma patients and to investigate the relationship between VD and structural parameters using optical coherence tomography angiography. Methods Our study included 25 primary open-angle glaucoma (POAG) patients, 25 pseudoexfoliation glaucoma (PXG) patients and 25 healthy individuals. All patients underwent 6 9 6 mm retinal angiography (upper limit: internal limitan membrane [ILM], lower limit: 10 lm inferior to inner plexiform layer) and 4.5 9 4.5 mm disk angiography (upper limit: ILM, lower limit: posterior border of the retinal nerve fiber layer [RNFL]) via an optical coherence tomography (OCT) system (AngioVue, Optovue). Measures of vascular density were as follows: total area VD (tVD), intrapapillary VD (iVD), peripapillary VD (pVD) and parafoveal VD (pfVD). In addition to performing comparisons, the correlations between pVD, retinal nerve fiber layer (RNFL) thickness and optic nerve head measurement results were investigated. B. S¸ . Durmus¸ Ece (&) Department of Ophthalmology, Mus¸ Public Hospital, Mus¸ , Turkey e-mail: [email protected]
Results A total of 75 individuals were included in our study. In the POAG and PXG groups, tVD and pVD values were significantly lower than the control group (median tVDs were: 45.4, 45.9, 50.0, and median pVDs were: 50.0, 50.3, 53.1, respectively) (confidence intervals were: - 9.8/- 1.1 for pVD and - 8.6/- 1.4 for tVD). Significantly lower pf-VD values were detected in the PXG group compared to the control group (p \ 0.05). There were strong positive correlations between RNFL thickness and pVD in in glaucoma groups (p \ 0.001). There was no correlation between pVD and disk area, intraocular pressure and age in glaucoma patients. Patients using beta-blockers had significantly lower tVD and pVD values compared to those who did not (p \ 0.05). Conclusion The low VD values in glaucomatous eyes and the strong correlations between that values and RNFL thickness demonstrate a relationship between structural parameters and vascular parameters. Keywords Optical coherence tomography angiography Vessel density Primary open-angle glaucoma Pseudoexfoliation glaucoma
M. S. Sarıcaog˘lu Department of Ophthalmology, University of Health Sciences Turkey, Ankara, Turkey e-mail: [email protected]
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Int Ophthalmol
Introduction Glaucoma is one of the leading causes of irreversible blindness worldwide [1]. There are studies in the literature showing the role of impaired ocular blood flow in glaucoma pathogenesis and these studies suggest that deterioration of blood flow to the optic nerve head (ONH) is not only a result of glaucomatous damage, but an early finding of
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