Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in
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ORIGINAL PAPER
Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab Toshifumi Asano . Hiroshi Kunikata . Masayuki Yasuda . Koji M. Nishiguchi . Toshiaki Abe . Toru Nakazawa
Received: 10 April 2020 / Accepted: 17 August 2020 Ó Springer Nature B.V. 2020
Abstract Purpose This study searched for early predictive vascular biomarkers for visual outcomes in eyes with macular edema caused by branch retinal vein occlusion (BRVOME). Methods Twenty-four eyes of 24 subjects with BRVOME were treated with the intravitreal injection of ranibizumab (IVR) for at least 6 months. We measured mean blur rate (MBR) in the optic nerve head (ONH) and vessel density (VD) in the macula with laser speckle flowgraphy and optical coherence tomography angiography, respectively. Results Six-month post-IVR best-corrected visual acuity (BCVA) was correlated positively with age, pre-IVR BCVA, 1-month post-IVR BCVA, 3-month post-IVR BCVA and pre-IVR systolic blood pressure
(P \ 0.001, P \ 0.001, P \ 0.001, P \ 0.001 and P = 0.02, respectively) and negatively with pre-IVR overall MBR, 1-month post-IVR overall MBR, 6-month post-IVR overall MBR, 3-month post-IVR deep retinal capillary plexus (DCP) VD and 6-month post-IVR DCP VD (P = 0.03, P = 0.03, P = 0.02, P = 0.01 and P = 0.005, respectively). Furthermore, a multiple regression analysis showed that pre-IVR overall MBR (b = - 0.67, P = 0.009) was among independent prognostic factors predicting 6-month post-IVR BCVA. Six-month post-IVR DCP VD was also correlated with overall MBR at all time points. Conclusion ONH blood flow may be a pre-IVR biomarker of both visual outcomes and post-IVR deep macular microcirculation in eyes with BRVOME.
T. Asano H. Kunikata (&) M. Yasuda T. Nakazawa Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan e-mail: [email protected]
T. Abe Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
H. Kunikata T. Nakazawa Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
T. Nakazawa Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
K. M. Nishiguchi T. Nakazawa Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
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Int Ophthalmol
Keywords Ocular blood flow Mean blur rate Macular capillary plexus Foveal avascular zone Optical coherence tomography angiography
Introduction Branch retinal vein occlusion (BRVO) and subsequent macular edema (BRVOME) are common retinal vascular conditions that cause severe visual disturbance. Previously, many kinds of approaches have been i
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