Expression of epidermal growth factor receptor is an independent prognostic factor for esophageal squamous cell carcinom
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RESEARCH
WORLD JOURNAL OF SURGICAL ONCOLOGY
Open Access
Expression of epidermal growth factor receptor is an independent prognostic factor for esophageal squamous cell carcinoma Qifeng Wang1,5†, Hongxia Zhu2†, Zefen Xiao1*, Wencheng Zhang1, Xiao Liu1, Xun Zhang3, Jie He4*, Kelin Sun4, Lvhua Wang1 and Ningzhi Xu2
Abstract Background: The overall survival of patients with esophageal squamous cell carcinoma (ESCC) remains poor. Prognostic predictions in ESCC are usually based on histological assessment of tumor invasion and lymph node metastasis, but a biomarker with better predictive accuracy could be more useful. Because overexpression of epidermal growth factor receptor (EGFR) has been associated with poor prognosis, this study investigated whether EGFR is an independent prognostic factor for overall survival and disease-free survival of ESCC patients. Methods: ESCC tissue specimens from 243 patients obtained during surgical resection between 1980 and 1997 were retrieved for immunohistochemical analysis of EGFR expression. Results: The data showed that EGFR protein was overexpressed in 187 of 243 (77%) ESCC tissues. Elevated expression was associated with higher pathologic tumor stages (P = 0.001), lymph node metastasis (P = 0.002), and higher Union for International Cancer Control (UICC) stage (P
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