Relationship between CT characteristics and human epidermal growth factor receptor 2 expression in gastric cancers
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ORIGINAL ARTICLE
Relationship between CT characteristics and human epidermal growth factor receptor 2 expression in gastric cancers Chang Liu1 · Feng Li2 · Hong‑Wei Zheng3 · · Qiu‑Xia Feng1 · Xi‑Sheng Liu1 · Liang Qi1 · Yu‑Dong Zhang1 Received: 12 November 2019 / Revised: 8 June 2020 / Accepted: 10 June 2020 © Springer Nature Singapore Pte Ltd. 2020
Abstract Objective Retrospectively analyzing the CT features and human epidermal growth factor receptor 2 (HER2)-expression status of patients with pathologically proven gastric cancers to investigate the potential correlation between them. Materials and methods 433 patients with gastric cancers confirmed by pathology underwent CT scan. According to HER2expression status, all patients were divided into two groups (HER2- negative [n = 300] and positive [n = 133]). CT features of primary gastric were reviewed and compared in both groups. CT findings were compared using Chi-square test, Fisher’s exact test, or the Student’s t test. Then binary logistic regression analysis was employed to identify the most significant differential CT features. Results Compared with HER2-negative gastric cancers, HER2-positive gastric cancers showed lower N stages (63.16% vs. 28.67%; p
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