Fabrication and Characterization of Non-spherical Polymeric Particles
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ORIGINAL ARTICLE
Fabrication and Characterization of Non-spherical Polymeric Particles Ajinkya Patil 1 & Sathish Dyawanapelly 2 & Prajakta Dandekar 2
&
Ratnesh Jain 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose The particle shape is a key factor influencing drug loading, drug release, cellular interaction, cell uptake, and in vivo distribution of micro- and nanoparticles. The purpose of the study was to develop a preliminary proof of concept about the fabrication of non-spherical particles from spherical nanoparticles by simple film stretching method. Methods The spherical Eudragit® S100 NPs was optimised with various parameters including, the concentration of the polymer, concentration of the surfactants, organic-aqueous phase ratio, and the speed of homogenization. Then, spherical NP-embedded polyvinyl alcohol (PVA) films were stretched to produce non-spherical particles. Finally, the resulting particle size and surface morphology of non-spherical Eudragit® S100 particles were analysed. Results Dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) have been utilised to analyse the size and morphology of particles, before and after film stretching. The resulting spherical NPs (< 150 nm) were successfully converted into monodispersed non-spherical, rod-like particles (< 500 nm) with precise shape control. Conclusion The present study provided a simple and economic method for developing non-spherical Eudragit® S100 polymeric particles. These particles could be used as promising colon-specific drug delivery or diagnostic system.
Keywords Eudragit . Non-spherical particles . Particle fabrication . Film stretching . Particle shape
Introduction The field of nanotechnology has enabled the application of different NPs in diverse disciplines such as chemical engineering, polymer science, mechanical engineering, cosmetics, solar energy, food technology, environmental and health sciences [1]. Amongst the various nanoparticulate systems, polymeric nanoparticles have been extensively studied in varied applications such as drug delivery, medical imaging, advanced materials and biomedical engineering [2]. However, in vitro and in vivo fate of polymeric NPs, used in the drug delivery platforms, is strongly influenced by their physicochemical properties such as size, shape and surface properties * Prajakta Dandekar [email protected] * Ratnesh Jain [email protected] 1
Department of Chemical Engineering, Institute of Chemical Technology, NP Marg, Matunga, Mumbai 400019, India
2
Department of Pharmaceutical Sciences & Technology, Institute of Chemical Technology, NP Marg, Matunga, Mumbai 400019, India
[3]. Size has a significant effect on cell uptake and circulation of NPs inside the body [4]. The surface chemistry of NPs influences their interactions with the cells and tissues inside the body [5]. Researchers have focused on surface modification of nanoparticles to minimise their recognition by the immune system
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