Fabrication of polyelectrolyte microspheres using porous manganese carbonate as sacrificial template for drug delivery a
- PDF / 684,470 Bytes
- 10 Pages / 584.957 x 782.986 pts Page_size
- 72 Downloads / 181 Views
Fabrication of polyelectrolyte microspheres using porous manganese carbonate as sacrificial template for drug delivery application Alexandro da Silva Abreu1, Janicy Arantes Carvalho1, Antonio Claudio Tedesco2, Milton Beltrame Junior1, Andreza Ribeiro Simioni1,a) 1
Organic Synthesis Laboratory, Research and Development Institute—IPD, Vale do Paraíba University, São José dos Campos 12244-000, Brazil Departament of Chemistry, Center of Nanotechnology and Tissue Engineering- Photobiology and Photomedicine (CNET), University of São Paulo, Ribeirão Preto, SP 14040-901, Brazil a) Address all correspondence to this author. e-mail: [email protected] 2
Received: 29 August 2018; accepted: 24 January 2019
This paper describes the fabrication of polyelectrolyte microspheres using porous manganese carbonate as a sacrificial template for entrapped photosensitizer (PS) drugs for photodynamic therapy application. These particles were used as templates for polyelectrolyte layer-by-layer assembly (Lbl) of two oppositely charged polyelectrolytes: poly(styrene sulfonate) and poly(allylamine hydrochloride). When the polyelectrolyte multilayer shell was built around the MnCO3 core by the Lbl protocol and the core was extracted with acid solution and EDTA, the resultant assembly consisted of hollow polyelectrolyte spheres. Chloroaluminum phthalocyanine was chosen as the model drug to load into the hollow spheres. All the spectroscopic results presented showed excellent photophysical parameters of the studied drug. The fabrication of polyelectrolyte hollow spheres can be used as an optimal medium for a variety of bioactive materials, which can also be encapsulated by the proposed method.
Introduction Photodynamic therapy (PDT) is a promising noninvasive localized treatment modality for a diverse range of diseases [1, 2, 3]. A nontoxic dye, called a “photosensitizer” (PS), capable of transferring light energy to other molecules, is administered to the patients with subsequent exposure to a light source of a specific wavelength that leads to the death of the target cell via oxidative damage [4]. PDT combines a photoactivatable PS, light, reactive oxygen species (ROS), and singlet oxygen (1O2), which leads to the death of cells [5]. Chloroaluminum phthalocyanine (ClAlPc), which has an aluminum(III) atom coordinated at the central position of the Pc macrocycle (Fig. 1), is a second-generation PS. A remarkable property of ClAlPc is its capability of producing at high quantum yields relatively long-lived singlet and triplet oxygen states. However, ClAlPc is hydrophobic, and thus, it requires advanced technologies to formulate nanostructured delivery systems to promote its dispersion in a physiological environment, improve
ª Materials Research Society 2019
the specific uptake by targeted tissues, and enhance PDT efficiency [6]. Due to the hydrophobic nature of phthalocyanine, the drug delivery systems associated with these PSs require complex systems, such as liposomes [7, 8], nanoemulsion [9], nanocapsules [10], poly(D,L-lactide-co-glycolide) n
Data Loading...
