Factors affecting health-related quality of life in patients with skin disease: cross-sectional results from 8,789 patie
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(2020) 18:298
RESEARCH
Open Access
Factors affecting health-related quality of life in patients with skin disease: crosssectional results from 8,789 patients with 16 skin diseases Zehui He1, Gaetano Marrone2, Aihua Ou1, Hongxia Liu3, Lin Ma4, Ying Huang5, Yongmei Li6, Liyun Sun7, Yanping Bai8, Wali Liu9, Xushan Zha10 and Chuanjian Lu11,12*
Abstract Background: Many previous studies have reported factors that contribute to health-related quality of life (HRQoL) for a single skin disease. However, little is known about generalized factors associated with HRQoL across skin diseases. The objective of this study was to investigate overall HRQoL, and to identify factors related to severely impaired HRQoL among patients with 16 different skin diseases. Methods: A cross-sectional study of 9845 patients with skin disease was conducted in 9 hospitals in China. HRQoL was assessed with the Chinese version of the Skindex-29 which measures dermatology-specific health along three domains (symptoms, emotions and functioning). With the published Skindex-29 cut-off scores for severely impaired HRQoL, logistic regression models assessed the relationship between severely impaired HRQoL and demographic/ clinical characteristics, with adjustments for different skin diseases. To guarantee the models’ convergence, 16 skin diseases with frequencies of at least 100 were included, and the sample size was 8789. Results: Emotions was the most impaired aspect of HRQoL. Co-existing chronic diseases, 3 years or longer duration, and more severity were identified as associated factors for severely impaired HRQoL for each Skindex-29 domain, and for the aggregate. Being female, under 45 years old, and consuming alcohol were associated with a severely impaired emotion domain; Lack of exercise and smoking were associated with severely impaired symptoms and function domains, respectively. Conclusions: Skin diseases can affect many facets of HRQoL, but the emotional impairment deserves more attention. In addition to skin disease severity, this study shows that other chronic diseases and long duration are correlated with severely impaired HRQoL for patients with 16 clinical common skin diseases. This suggests the need for increased awareness in treating skin disease as a chronic disease. It also suggests that disease management decisions should consider HRQoL improvement, especially emotional conditions, when making management decisions. Keywords: Dermatology, Logistic models, Quality of life, Skin diseases * Correspondence: [email protected] 11 Department of Dermatology, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Da De Road, Yue Xiu District, Guangzhou 510120, Guangdong, China 12 Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, s
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