Factors predicting prognosis and recurrence in patients with esophago-gastric adenocarcinoma and histopathological respo
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ORIGINAL ARTICLE
Factors predicting prognosis and recurrence in patients with esophago-gastric adenocarcinoma and histopathological response with less than 10 % residual tumor Katja Ott & Susanne Blank & Karen Becker & Rupert Langer & Wilko Weichert & Wilfried Roth & Leila Sisic & Annika Stange & Dirk Jäger & Markus Büchler & Jörg-Rüdiger Siewert & Florian Lordick
Received: 11 October 2012 / Accepted: 5 December 2012 / Published online: 27 December 2012 # Springer-Verlag Berlin Heidelberg 2012
Abstract Purpose Neoadjuvant treatment is an accepted standard approach for treating locally advanced esophago-gastric adenocarcinomas. Despite a response of the primary tumor, a significant percentage dies from tumor recurrence. The aim of this retrospective exploratory study from two academic centers was to identify predictors of survival and recurrence in histopathologically responding patients. Methods Two hundred thirty one patients with adenocarcinomas (esophagus: n0185, stomach: n046, cT3/4, cN0/+, cM0) treated with preoperative chemotherapy (n0212) or chemoradiotherapy (n 019) followed by resection achieved a Ott Katja and Blank Susanne contributed equally to this work. K. Ott (*) : S. Blank : L. Sisic : M. Büchler Department of Surgery, University Hospital of Heidelberg, Heidelberg, Germany e-mail: [email protected] K. Becker : R. Langer Institute of Pathology, Technical University, Munich, Germany W. Weichert : W. Roth Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany A. Stange : D. Jäger National Center of Tumor Diseases, University of Heidelberg, Heidelberg, Germany
histopathological response (regression 1a: no residual tumor (n058), and regression 1b
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