Faecal microbiota transplantation to chronic pouchitis improves quality of life: a pilot study
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LETTER TO THE EDITOR
Faecal microbiota transplantation to chronic pouchitis improves quality of life: a pilot study Sabrina Just Kousgaard 1,2
&
Hans Linde Nielsen 2,3 & Karina Frahm Kirk 4 & Ole Thorlacius-Ussing 1,2
Accepted: 17 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Dear Editor: We read the article by Fang et al. describing a case with sustained response to treatment of chronic pouchitis with a single faecal microbiota transplantation (FMT) with great interest [1]. While previous studies have investigated FMT for the treatment of chronic pouchitis with diverging clinical results, almost all have exclusively used the Pouchitis Disease Activity Index (PDAI) to assess the effect of FMT. Fang et al. also reported that FMT improved the patient’s quality of life, using the Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and Cleveland Global Quality of Life (CGQL) for assessment. We aimed to assess quality of life measurements of FMT in chronic pouchitis, in a pilot study on nine patients receiving FMT for chronic pouchitis. Patients were allocated to treatment with FMT delivered by enema from five faecal donors for 14 consecutive days [2]. At baseline and 30-day follow-up, patients underwent a pouchoscopy, and the PDAI was assessed. In addition, clinical items of the PDAI score were also assessed at 14-day follow-up. Quality of life questionnaires were collected at baseline, 14-day follow-up and 30-day follow-up, using SIBDQ (score from 10 to 70 points indicating low to high quality of life) [3]. Sexual function questionnaires were completed at baseline and 30-day follow-up using Female Sexual Function Index (FSFI) for females and International Index of Erectile Function (IIEF) for
* Sabrina Just Kousgaard [email protected]
males (scores from 2 to 36 and 6 to 75 points indicating low to high sexual function) [4, 5]. At 14-day follow-up, SIBDQ increased to mean 49.4 (SD 12.4) from a baseline mean value of 43.0 (SD 14.2) and sustained at mean 48.0 (SD 9.4) at 30-day follow-up. For sexual function, both FSFI and IIEF increased from baseline (FSFI mean 24.1, SD 5.0; IIEF mean 33.0, SD 32.5) to 30-day followup (FSFI mean 30.1, SD 1.9; IIEF mean 45.5, SD 16.3). Simultaneously with improvement of quality of life, the PDAI score decreased from mean 8.6 at baseline to mean 5.2 at 30-day follow-up [2]. Pearson correlation coefficient was used to test for a correlation between the PDAI score and SIBDQ at 14- and 30-day follow-up. At 14-day follow-up, a correlation coefficient of − 0.51 was found between the clinical PDAI score and SIBDQ, indicating a moderate correlation. Furthermore, at 30-day follow, a strong correlation was found, with a correlation coefficient of − 0.90 between the PDAI score and SIBDQ. Fang et al. found that SIBDQ increased to 52 from 30 at 3-month follow-up compared with baseline [1]. Furthermore, at 3-month follow-up, the modified PDAI score decreased to 0 from 10 at baseline. We did not assess quality of life beyond the 30-day follow-up and therefore cannot m
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