Colonoscopic screening for colorectal cancer improves quality of life measures: a population-based screening study
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Colonoscopic screening for colorectal cancer improves quality of life measures: a population-based screening study Doug Taupin*, Sharon L Chambers, Mike Corbett and Bruce Shadbolt Address: Gastroenterology and Hepatology Unit and Centre for Advances in Epidemiology and Information Technology, The Canberra Hospital, Yamba Drive, Garran, Australian Capital Territory, Australia Email: Doug Taupin* - [email protected]; Sharon L Chambers - [email protected]; Mike Corbett - [email protected]; Bruce Shadbolt - [email protected] * Corresponding author
Published: 18 October 2006 Health and Quality of Life Outcomes 2006, 4:82
doi:10.1186/1477-7525-4-82
Received: 27 July 2006 Accepted: 18 October 2006
This article is available from: http://www.hqlo.com/content/4/1/82 © 2006 Taupin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Screening asymptomatic individuals for neoplasia can have adverse consequences on quality of life. Colon cancer screening is widespread but the quality of life (QOL) consequences are unknown. This study determined the impact of screening colonoscopy on QOL measures in asymptomatic average-risk participants. Methods: Asymptomatic male and female participants aged 55–74 years were randomly selected from the Australian Electoral Roll or six primary care physicians' databases. Participants completed the Short-Form (SF-36) Quality of Life Assessment at baseline and at a mean of 39 days after colonoscopy. Outcome measures were (i) significant changes in raw scores in any of the eight SF36 domains assessed following colonoscopic screening and (ii) improvements or declines in previously validated categories, representing clinically significant changes, within any of the eight SF36 domains. Results: Baseline QOL measures were similar to those of a matched general population sample. Role Limitations due to Emotions, Mental Health and Vitality raw scores significantly improved following colonoscopy (P < 0.05, 2-tailed t-test). Health ratings according to Category were similar (same clinical status) in the majority of participants. However, 30% participants recorded clinically significant improvement in the Mental Health and Vitality domains (P < 0.05, Wilcoxon SignedRanks test). This improvement was not offset by declines in other domains or in other participants. Improvement in QOL was not related to colonoscopy results. Conclusion: Average-risk persons benefit significantly from colon cancer screening with colonoscopy, improving in Mental Health and Vitality domains of Quality of Life. This improvement is not offset by declines in other domains.
Background Colorectal cancer is a common disease with a long leadtime and easily recognised precursor lesions, making screening a
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