Fas Signaling
Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proin
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Fas Signaling
Harald Wajant, Prof., Ph.D. Department of Molecular Internal Medicine Medical Clinic and Polyclinic II University of Wuerzburg Wuerzburg, Germany
LANDES BIOSCIENCE / EuREKAH.coM GEORGETOWN, TEXAS
U.S.A.
SPRINGER SCIENCE+BUSINESS MEDIA NEW YORK, NEW YORK
U.SA
FAS SIGNALING Medical Intelligence Unit Landes Bioscience Springer Science+Business Media, Inc. ISBN: 0-387-32172-1
Printed on acid-free paper.
Copyright ©2006 Landes Bioscience and Springer Science+Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher, except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. T h e use in the publication of trade names, trademarks, service marks and similar terms even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Springer Science+Business Media, Inc., 233 Spring Street, New York, New York 10013, U.S.A. http://www.springer.com Please address all inquiries to the Publishers: Landes Bioscience, 810 South Church Street, Georgetown, Texas 78626, U.S.A. Phone: 512/ 863 7762; FAX: 512/ 863 0081 http://www.eurekah.com http://www.landesbioscience.com Printed in the United States of America. 9 8 7 6 5 4 3 2 1
Library of Congress Cataloging-in-Publication Data Fas signaling / edited by Harald Wajant. p. ; cm. ~ (Medical intelligence unit) Includes bibliographical references and index. ISBN 0-387-32172-1 1. C D antigens. 2. Cellular signal transduction. I. Wajant, Harald. II. Title. III. Series: Medical intelligence unit (Unnumbered : 2003) [DNLM: 1. Antigens, C D 9 5 . 2. Adaptor Proteins, Signal Transducing. 3. Membrane Glycoproteins. Q W 573 F248 2006] QR186.6.C42F37 2006 571.7'4-dc22
2006004030
CONTENTS Preface 1. FasL and Fas: Typical Members of the TNF Ligand and Receptor Family Anja Krippner-Heidenreich and Peter Scheurich The T N F Receptor and T N F Ligand Superfamilies Identification of Fas and Its Ligand The Membrane Receptor Fas Fas Expression The Fas Ligand Membrane Bound and Soluble FasL Receptor Ligand Complexes Fas Signaling 2. FasL-Independent Activation of Fas Faustina Mollinedo and Consuelo Gajate F
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