GM3 Signaling
This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma ce
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GM3 Signaling
GM3 Signaling
Cheorl-Ho Kim
GM3 Signaling
Cheorl-Ho Kim Molecular and Cellular Glycobiology Lab Department of Biological Sciences College of Science, Sungkyunkwan University Suwon, Korea
ISBN 978-981-15-5651-7 ISBN 978-981-15-5652-4 https://doi.org/10.1007/978-981-15-5652-4
(eBook)
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Contents
1
History of Sialic Acids, Gangliosides, and GM3 . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1 2
2
Synthesis of GM3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3
3
Molecular Localization of GM3 in Cells . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
7 8
4
Basic Function of GM3 as an Interacting Molecule . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9 12
5
GD3 Mimetics with a Neurite Forming Capacity . . . . . . . . . . . . . . 5.1 GD3 Mimetic of Deuterostome Echinoderms . . . . . . . . . . . . . 5.2 GM4-Type and Hematoside-Type Ganglioside Show Immune-Modulating Capacities . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. .
13 13
. .
14 14
6
GM3 as a Pathogenic Infection Receptor . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
17 19
7
GM3 and Related Gangliosides Prevent In
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