Feasibility and reproducibility of T2 mapping and DWI for identifying malignant lymph nodes in rectal cancer
- PDF / 4,151,294 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 39 Downloads / 191 Views
GASTROINTESTINAL
Feasibility and reproducibility of T2 mapping and DWI for identifying malignant lymph nodes in rectal cancer Yu-xi Ge 1 & Shu-dong Hu 1 & Zi Wang 1 & Rong-ping Guan 1 & Xin-yi Zhou 2 & Qi-zhong Gao 3 & Gen Yan 4 Received: 5 March 2020 / Revised: 27 August 2020 / Accepted: 25 September 2020 # European Society of Radiology 2020
Abstract Objectives To evaluate the diagnostic value and reproducibility of T2 mapping versus apparent diffusion coefficients (ADC) for identifying malignant lymph nodes in patients with non-mucinous rectal adenocarcinoma. Methods High-resolution magnetic resonance imaging, diffusion-weighted imaging, and T2 mapping were performed on patients with suspected metastatic lymph nodes in the mesorectum or around the superior rectal artery with a short-axis diameter of 4–10 mm. The T2 and ADC values of pathology-confirmed metastatic versus non-metastatic lymph nodes were compared using the independent-samples t test and receiver operating characteristic curves. Intra- and inter-observer reproducibility were tested. The cutoff value for T2 relaxation time was determined. Results In total, 67 lymph nodes underwent histological analysis, with 24 in the non-metastatic and 43 in the metastatic groups. Intra- and inter-observer agreements for T2 values were 0.999 and 0.998, respectively, which were higher than the ADC values of 0.924 and 0.844, respectively. The mean T2 and ADC values for metastatic lymph nodes (65 ± 7.8 ms and 1.17 ± 0.16 × 10−3 mm2/s, respectively) were significantly lower than for benign lymph nodes(83 ± 5.7 ms and 1.29 ± 0.15 × 10−3 mm2/s, respectively). T2 values had a higher AUC value of 0.990 than the AUC value for ADC of 0.729. With a cutoff value of 77 ms, sensitivity and specificity for T2 values were 95% and 96%, respectively. Conclusions T2 mapping had higher diagnostic efficacy and reproducibility than ADC and may be useful in differentiating metastatic from non-metastatic lymph nodes in rectal cancer. Key Points • Mean T2 values were significantly shorter for malignant versus benign LNs in patients with non-mucinous rectal adenocarcinoma. • The diagnostic efficacy and reproducibility of T2 values were excellent and superior to ADC values. Keywords Magnetic resonance imaging . Rectal cancer . Lymph nodes . Metastatic
Abbreviations ADC Apparent diffusion coefficient AUC Area under the curve CRT Chemoradiotherapy DWI Diffusion-weighted imaging FOV Field of view ICC Intraclass coefficient LN Lymph node
LNM LoA MRI ROC ROI T2WI TE TME
* Qi-zhong Gao [email protected]
2
Department of Pathology, Affiliated Hospital of Jiangnan University, 200 Huihe Road, Wuxi, Jiangsu, China
* Gen Yan [email protected]
3
Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University, 200 Huihe Road, Wuxi 214000, Jiangsu, China
4
Department of Radiology, The Second Affiliated Hospital of Xiamen Medical College, 556 Shengguang Road, Xiamen 361021, Fujian, China
1
Department of Radiology, Affiliated Hospital of Jiangnan University, 200 Huihe Road, Wux
Data Loading...
