Feasibility and safety of high-dose adenosine perfusion cardiovascular magnetic resonance imaging
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POSTER PRESENTATION
Open Access
Feasibility and safety of high-dose adenosine perfusion cardiovascular magnetic resonance imaging Theodoros D Karamitsos*, Ntobeko BA Ntusi, Jane M Francis, Cameron J Holloway, Saul G Myerson, Stefan Neubauer From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Objective The aim of the present study was to assess the tolerance and safety of a high-dose adenosine protocol (210mcg/ kg/min) in patients with inadequate hemodynamic response to the standard adenosine dose (140mcg/kg/ min) when undergoing CMR perfusion imaging. Introduction Adenosine is the most widely used vasodilator stress agent for Cardiovascular Magnetic Resonance (CMR) perfusion studies. With the standard dose of 140 mcg/ kg/min some patients fail to demonstrate characteristic hemodynamic changes: a significant increase in heart rate (HR) and mild decrease in systolic blood pressure (SBP). Whether an increase in the rate of adenosine infusion would improve peripheral and, likely, coronary vasodilatation in those patients is unknown. Methods 98 consecutive patients with known or suspected coronary artery disease (CAD) underwent CMR perfusion imaging at 1.5 Tesla. Subjects were screened for contraindications to adenosine, and an electrocardiogram was performed prior to the scan. All patients initially received the standard adenosine protocol (140 mcg/kg/ min for at least 3 minutes). If the hemodynamic response was inadequate (HR increase
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