Feasibility of perfusion cardiovascular magnetic resonance in paediatric patients
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BioMed Central
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Feasibility of perfusion cardiovascular magnetic resonance in paediatric patients Emanuela R Valsangiacomo Buechel*1, Christian Balmer1, Urs Bauersfeld1, Christian J Kellenberger2 and Juerg Schwitter3 Address: 1University Children's Hospital Zurich, Division of Paediatric Cardiology, 8032 Zurich, Switzerland, 2University Children's Hospital Zurich, Division of Diagnostic Imaging, 8032 Zurich, Switzerland and 3University Hospital Zurich, Clinic of Cardiology, Zurich, Switzerland Email: Emanuela R Valsangiacomo Buechel* - [email protected]; Christian Balmer - [email protected]; Urs Bauersfeld - [email protected]; Christian J Kellenberger - [email protected]; Juerg Schwitter - [email protected] * Corresponding author
Published: 30 November 2009 Journal of Cardiovascular Magnetic Resonance 2009, 11:51
doi:10.1186/1532-429X-11-51
Received: 18 June 2009 Accepted: 30 November 2009
This article is available from: http://www.jcmr-online.com/content/11/1/51 © 2009 Buechel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Aims: As coronary artery disease may also occur during childhood in some specific conditions, we sought to assess the feasibility and accuracy of perfusion cardiovascular magnetic resonance (CMR) in paediatric patients. Methods and results: First-pass perfusion CMR studies were performed under pharmacological stress with adenosine and by using a hybrid echo-planar pulse sequence with slice-selective saturation recovery preparation. Fifty-six perfusion CMR examinations were performed in 47 patients. The median age was 12 years (1 month-18 years), and weight 42.8 kg (2.6-82 kg). General anaesthesia was required in 18 patients. Mean examination time was 67 ± 19 min. Diagnostic image quality was obtained in 54/56 examinations. In 23 cases the acquisition parameters were adapted to patient's size. Perfusion CMR was abnormal in 16 examinations. The perfusion defects affected the territory of the left anterior descending coronary artery in 11, of the right coronary artery in 3, and of the circumflex coronary artery in 2 cases. Compared to coronary angiography, perfusion CMR showed a sensitivity of 87% (CI 52-97%) and a specificity of 95% (CI 79-99%). Conclusion: In children, perfusion CMR is feasible and accurate. In very young children (less than 1 year old), diagnostic image quality may be limited.
Introduction Coronary artery disease (CAD) in paediatric patients may occur after surgery for congenital heart disease involving the coronary arteries, after surgery for congenital coronary anomalies or in patients with an inflammatory disease affecting the mid- and small-size arteries such as Kawasaki disease or Takayasu arteritis [1-3]. Therefore a
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