Feasibility of regional left ventricular endocardial curvature analysis from cardiac magnetic resonance images
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BioMed Central
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Feasibility of regional left ventricular endocardial curvature analysis from cardiac magnetic resonance images Francesco Maffessanti*1, Roberto M Lang2, Johannes Niel3, Regina SteringerMacherbauer3, Enrico G Caiani1, Hans-Joachim Nesser4 and Victor Mor-Avi2 Address: 1Politecnico di Milano, Milan, Italy, 2University of Chicago, Chicago, IL, USA, 3Public Hospital ELisabethinen, Linz, Austria and 4Public Hospital Elisabethinen, Linz, Austria * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P236
doi:10.1186/1532-429X-12-S1-P236
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P236 © 2010 Maffessanti et al; licensee BioMed Central Ltd.
Introduction Left ventricular (LV) remodeling is usually assessed using changes in LV volume. Because this methodology describes only global effects of remodeling while disregarding changes in ventricular shape that may occur independently of volume, the importance of shape analysis is increasingly recognized. While most previous studies focused on global LV shape, we hypothesized that 3D analysis of regional endocardial curvature could provide clinically useful information on localized remodeling.
Purpose To test the feasibility of applying this approach to cardiac magnetic resonance (CMR) images and to investigate regional differences in endocardial curvature in normal and hypokinetic ventricles.
Methods We studied 38 patients: 14 with normal LV function (NL), 6 with idiopathic dilated cardiomyopathy (IDC), and 18 with wall motion abnormalities secondary to ischemic heart disease (IHD). Steady-state free precession images (Siemens 1.5 T) were obtained in short-axis views from base to apex as well as 2-, 3- and 4-chamber views. After endocardial boundaries were initialized in the long axis views, LV endocardial surface was semi-automatically reconstructed throughout the cardiac cycle (LV Analysis MR, TomTec). Custom software was used to calculate for each point on the surface the maximum curvature and the curvature in the perpendicular direction, and local surface curvedness (C) was calculated as the root mean square. C
values were averaged using standard 17-segment model and compared between groups of segments: NL (N = 401), IDC (N = 98) and IHD (N = 153) using one-way ANOVA.
Results In all normal segments, C gradually increased during systole and then decreased during diastole (figure). While both maximum and minimum values of C were comparable in the 6 basal and 6 mid-ventricular segments, they were significantly higher in the 4 apical segments and highest in the apical cap. Additionally, percent change in C was higher in mid and apical
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