Fight Back: Adaptive Responses to Toxicant Exposure
The popularity of barbiturate sedatives in bygone days helped physicians discover an unusual property of these medicines: on repeated use, patients experienced a dramatic loss of effectiveness, with higher and higher doses required to elicit the original
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An Introduction to Toxicology
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An Introduction to Toxicology
Philip C. Burcham
An Introduction to Toxicology
Philip C. Burcham School of Medicine and Pharmacology The University of Western Australia Perth Western Australia Australia
ISBN 978-1-4471-5552-2 ISBN 978-1-4471-5553-9 DOI 10.1007/978-1-4471-5553-9 Springer London Heidelberg New York Dordrecht
(eBook)
Library of Congress Control Number: 2013954873 © Springer-Verlag London 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
For my wonderful parents
About the Author
After undergraduate majors in chemistry and pharmacology, Phil Burcham completed a Ph.D. in biochemical toxicology in 1990 under the supervision of Dr. Andrew W Harman at the University of Western Australia. He then completed postdoctoral training in molecular toxicology under Lawrence J Marnett at Vanderbilt University. After teaching pharmacology and toxicology at the University of Adelaide for 12 years, he returned to Perth to establish a research group focused on studying noxious smoke constituents. His research efforts have led to 55 scientific publications. He has over 20 years of experience in teaching toxicology, pharmacology and drug metabolism to science, medicine, pharmacy, podiatry and dentistry students. His popula
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