Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure
- PDF / 769,041 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 23 Downloads / 179 Views
ORIGINAL ARTICLE
Multiorgan contribution to non‑shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans Hitoshi Wakabayashi1 · Kentaro Matsumoto1 · Yusuke Kobori1 · Tasuku Ebara1 · Mami Matsushita2 · Toshimitsu Kameya3 · Takafumi Maeda4 · Masayuki Saito5 Received: 8 April 2020 / Accepted: 5 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Human brown adipose tissue (BAT) is known to be a significant thermoeffector in non-shivering thermogenesis (NST), albeit with individual variations in the BAT activity. We hypothesized that humans with less BAT would have more contribution from the skeletal muscle (SM) to NST or earlier shivering onset and greater vasoconstriction to compensate for less BAT-mediated thermogenesis. Methods Eighteen males participated in this study. Their BAT activity and detectable volume were investigated. A gradual cold exposure was conducted for inducing NST at 18.6 °C and initiating shivering at 11.6 °C. The energy expenditure, electromyograph of the pectoralis major, skin blood flow, and rectal (Tre) and skin temperatures were evaluated. Results BAT volume significantly correlated with the change in metabolic heat production during mild cold phase relative to baseline (NST; r = 0.562, P
Data Loading...
