Fluorescence Microscopy: Single Particle Tracking
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Fabrication Definition
Factor Inhibiting HIF–1 ▶FIH
Fabrication is the art of building or making from raw materials. ▶Proteomics in Microfluidic Systems
FAD Fabry Disease
▶Familial Alzheimer’s Disease ▶Alzheimer’s Disease
Definition Fabry disease is an X-linked recessive lysosomal storage disease with cardiovascular, renal and lenticular abnormalities, resulting from the deficient activity of the exogalactosidase, alpha-galactosidase A (alpha-Gal A). Phenotypic expression in female heterozygous carriers depends on ▶lyonization.
FACS Fluorescence activated cell sorting, ▶flow cytometry.
F-Actin ▶Actin Cytoskeleton ▶Tangier Disease
FADD ▶Fas-Associated Death Domain
FAK Definition FAK stands for Focal Adhesion Kinase. It is a nonreceptor proteintyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. FAK plays a potential role in oncogenic transformations resulting in increased kinase activity. ▶Signal Transduction: Integrin-Mediated Pathways
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False Positives/False Negatives
False Positives/False Negatives
Familial Amyotrophic Lateral Sclerosis
Definition False positives (or false negatives, respectively) exist when laboratory tests or biometric scans report, incorrectly, that they have found a signal where none exists in reality (or found no signal although one exists in reality). For example, a positive test for AIDS or cancer, when the person was disease free, would be a false positive. In a ▶two-hybrid screen, false positives are physiological protein-protein interactions, which cannot be confirmed by another method. ▶Two-Hybrid System
Definition Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease that attacks the nerve cells responsible for controlling voluntary muscles. The disease belongs to a group of disorders known as motor neuron diseases, which are characterized by the gradual degeneration and death of motor neurons. Mutations in Cu/Zn superoxide dismutase–1 (SOD) have been identified as a genetic cause of the inherited familial form of ALS. ▶Peptidy Prolyl Cis/Trans Isomerases
Familial Combined Hyperlipidemia Familial Adenomatous Polyposis Definition Familial adenomatous polyposis (FAP) is an autosomal dominantly transmitted syndrome associated with an increased risk of colorectal cancer. It is characterized by the development of hundreds to thousands of adenomatous polyps of the colorectum during the second and third decade of life. ~80% of the FAP patients harbour truncating germ-line mutations in the ▶APC (Adenomatous Polyposis Coli) tumor suppressor gene. ▶Colorectal Cancer ▶Gut Epithelium ▶Hereditary Nonpolyposis Colorectal Cancer ▶Predictive Genetic Testing
Definition Familial combined hyperlipidemia is an inherited disorder of high serum cholesterol an
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