FocusDET, A New Toolbox for SISCOM Analysis. Evaluation of the Registration Accuracy Using Monte Carlo Simulation
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ORIGINAL ARTICLE
FocusDET, A New Toolbox for SISCOM Analysis. Evaluation of the Registration Accuracy Using Monte Carlo Simulation Berta Martí Fuster & Oscar Esteban & Xavier Planes & Pablo Aguiar & Cristina Crespo & Carles Falcon & Gert Wollny & Sebastià Rubí Sureda & Xavier Setoain & Alejandro F. Frangi & Maria J. Ledesma & Andrés Santos & Javier Pavía & Domènec Ros Published online: 19 August 2012 # Springer Science+Business Media, LLC 2012
Abstract Subtraction of Ictal SPECT Co-registered to MRI (SISCOM) is an imaging technique used to localize the epileptogenic focus in patients with intractable partial epilepsy. The aim of this study was to determine the accuracy B. Martí Fuster : C. Crespo : C. Falcon : D. Ros (*) Unitat de Biofísica i Bioenginyeria, Departament de Ciències Fisiològiques I, Facultat de Medicina, Universitat de Barcelona-IDIBAPS, C/Casanova 143 – Planta 5 (Ala Nord), E08036 Barcelona, Spain e-mail: [email protected] B. Martí Fuster e-mail: [email protected] C. Crespo e-mail: [email protected] C. Falcon e-mail: [email protected] B. Martí Fuster : O. Esteban : X. Planes : C. Falcon : G. Wollny : A. F. Frangi : M. J. Ledesma : A. Santos : J. Pavía : D. Ros Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Campus Río Ebro – Edificio I+D Bloque 5, 1ª planta C/Poeta Mariano Esquillor s/n, E50018 Zaragoza, Spain O. Esteban e-mail: [email protected] X. Planes e-mail: [email protected]
of registration algorithms involved in SISCOM analysis using FocusDET, a new user-friendly application. To this end, Monte Carlo simulation was employed to generate realistic SPECT studies. Simulated sinograms were J. Pavía e-mail: [email protected] O. Esteban : G. Wollny : M. J. Ledesma : A. Santos Biomedical Image Technologies, Departamento de Ing. Electrónica, ETSI Telecomunicación, Universidad Politécnica de Madrid, Av. Complutense s/n (Lab. C203), E28040 Madrid, Spain X. Planes : A. F. Frangi Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Information and Communications Technology Department, Universitat Pompeu Fabra, C/Tanger 122-140, E08018 Barcelona, Spain
P. Aguiar Servizo de Medicina Nuclear, Fundación IDICHUS, Complexo Hospitalario Universitario de Santiago de Compostela, Rúa da Choupana s/n, E15706 Santiago de Compostela, Spain e-mail: [email protected]
A. F. Frangi e-mail: [email protected]
S. Rubí Sureda : X. Setoain : J. Pavía Servei de Medicina Nuclear, Hospital Clínic, IDIBAPS, C/Villarroel 170, E08036 Barcelona, Spain
M. J. Ledesma e-mail: [email protected]
S. Rubí Sureda e-mail: [email protected]
A. Santos e-mail: [email protected]
X. Setoain e-mail: [email protected]
G. Wollny e-mail: [email protected]
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reconstructed by using the Filtered BackProjection (FBP) algorithm and an Ordered Subsets Expectation Maximization (OSEM) reconstruction method that included compensation for all degradations. Registration errors in SPECT-SPECT and SPECT-MRI registration were evaluated by comparing
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