French Value-Set of the QLU-C10D, a Cancer-Specific Utility Measure Derived from the QLQ-C30
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ORIGINAL RESEARCH ARTICLE
French Value‑Set of the QLU‑C10D, a Cancer‑Specific Utility Measure Derived from the QLQ‑C30 Virginie Nerich1,2 · Eva Maria Gamper3 · Richard Norman4 · Madeleine King5,6 · Bernhard Holzner3 · Rosalie Viney7 · Georg Kemmler8
© Springer Nature Switzerland AG 2020
Abstract Background and objective The EORTC Quality of Life Utility Measure-Core 10 Dimensions (QLU-C10D) is a new multiattribute utility instrument derived from the EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), a widely used cancer-specific quality-of-life questionnaire. It covers ten dimensions: physical, role functioning, social, emotional functioning, pain, fatigue, sleep, appetite, nausea and bowel problems. To allow national health preferences to be reflected, country-specific valuations are being performed through collaboration between the Multi-Attribute Utility Cancer (MAUCa) Consortium and the EORTC. The aim of this study was to determine the utility weights for health states in the French version of the QLU-C10D. Methods Valuations were run in a web-based setting in a general population sample of 1033 adults. Utilities were elicited using a discrete-choice experiment (DCE). Data were analyzed by conditional logistic regression and mixed logits. Results The sample was representative of the general French population in terms of gender and age. Dimensions with the largest impact on utility weights were, in this order: physical functioning, pain and emotional functioning. The impact on utilities was lower for role functioning, nausea, bowel problems and social functioning. The dimensions of sleep, fatigue and lacking appetite were associated with the smallest utility decrement. Conclusion The results of the present study provide utility weights for the QLU-C10D and offer interesting prospects, as some cancer-specific dimensions also received sizeable utility weights (nausea and bowel problems). In fact, the EQ-5D and the HUI 3 are recommended in France and commonly used for cancer-related CUA; however, both these instruments are generic. The availability of a new cancer-specific utility instrument, such as the QLU-C10D, could improve the quality and the pertinence of future CUA in oncology
Key Points for Decision Makers The EORTC QLU-C10D is a new cancer-specific multiattribute utility instrument derived from the EORTC QLQ-C30, a widely used quality-of-life questionnaire in oncology.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40258-020-00598-1) contains supplementary material, which is available to authorized users.
The utility weights for health states in the French version of the QLU-C10D has been estimated in the general population; dimensions with the largest impact on utility weights were, in this order: physical functioning, pain, and emotional functioning. Among cancer-specific dimensions, both nausea and bowel problems received sizeable utility weights.
* Virginie Nerich v1nerich@chu‑besancon.fr Extended author information available on the
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