From Neural Networks and Biomolecular Engineering to Bioelectronics

This volume represents the fIrst of a series of proceedings of the EL.B.A. Forum on Bioelectronics, a scientifIc discipline at the frontiers of Advanced Electronics and Biotechnology. The name for these forums derives not only from the place (the Isle of

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ELECTRONICS AND BIOTECHNOLOGY ADVANCED (EL.B.A.) FORUM SERIES Volume 1

FROM NEURAL NETWORKS AND BIOMOLECULAR ENGINEERING TO BIOELECTRONICS Edited by Claudio Nicolini

A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

From Neural Networks and Biomolecular Engineering to Bioelectronics Edited by

Claudio Nicolini Institute of Biophysics University of Genoa Genoa, Italy

Assistant Editor Sergei Vakula EL.B.A. Foundation Portoferraio, Italy

Springer Science+ Business Media, LLC

Library of Congress Cataloging-in-Publication Data On file

Proceedings of the 1993 International Workshop on Electronics and Biotechnology Advanced, held July 13-16, 1993, on the Isle of Elba, Italy

ISBN 978-1-4899-1090-5 ISBN 978-1-4899-1088-2 (eBook) DOI 10.1007/978-1-4899-1088-2 © Springer Science+Business Media New York 1995 Originally published by Plenum Press, New York in 1995 Softcover reprint of the hardcover 1st edition 1995 10 9 8 7 6 5 4 3 2 1 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher

PREFACE

This volume represents the fIrst of a series of proceedings of the EL.B.A. Forum on Bioelectronics, a scientifIc discipline at the frontiers of Advanced Electronics and Biotechnology. The name for these forums derives not only from the place (the Isle of Elba in Italy), where the conferences have been held every 6 months since 1991, but also from an acronym: Electronics and Biotechnology Advanced. Bioelectronics is intended as "the use of biological materials and biological architectures for information processing and sensing systems and devices down to molecular level" and focuses its attention on three major areas: I New hardware architectures borrowed from the thorough study of brain and sensory systems down to the molecular level, utilizing existing semiconductor inorganic materials (both GaAs and Si) and giga-scale integration; II Protein Engineering, especially of systems involved in electron transfer and molecular recognition, integrated with Metabolism and Chemical Engineering, to develop new biomaterials by learning basic rules of macromolecular folding and self-assembly; m Sensors, thin film and electronic devices utilizing organic compounds and biopolymers, and by implementing nanotechnology bottom up through manufacturing and characterization at the atomic level. Bioelectronics, at the interface of biotechnology and electronics, has been characterized by the Italian Government, as early as 1989, as one of the fIelds of strategic importance for scientifIc and technological research and for potential industrial development. The decision, made in 1989 by the Italian Government, was revolutionary in this fIeld in that for t