Modeling Biomolecular Networks in Cells Structures and Dynamics
Taking ideas from nature has been a theme of humanity’s technological progress but it is only our newfound expertise in molecular manipulation and complex nonlinear dynamics that allows us the prospect of conscripting the building blocks of life as a mean
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Luonan Chen · Ruiqi Wang · Chunguang Li Kazuyuki Aihara
Modeling Biomolecular Networks in Cells Structures and Dynamics
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Prof. Luonan Chen Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 200233 Shanghai China [email protected]
Prof. Ruiqi Wang Institute of Systems Biology Shanghai University 200444 Shanghai China [email protected]
Prof. Chunguang Li Department of Information Science and Electronic Engineering Zhejiang University 310027 Hangzhou China [email protected]
Prof. Kazuyuki Aihara University of Tokyo 153-8505 Tokyo Japan [email protected]
ISBN 978-1-84996-213-1 e-ISBN 978-1-84996-214-8 DOI 10.1007/978-1-84996-214-8 Springer London Dordrecht Heidelberg New York British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Control Number: 2010930911 © Springer-Verlag London Limited 2010 MATLAB® and Simulink® are registered trademarks of The MathWorks, Inc., 3 Apple Hill Drive, Natick, MA 01760-2098, U.S.A. http://www.mathworks.com Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency. Enquiries concerning reproduction outside those terms should be sent to the publishers. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore free for general use. The publisher makes no representation, express or implied, with regard to the accuracy of the information contained in this book and cannot accept any legal responsibility or liability for any errors or omissions that may be made. Cover design: eStudioCalamar, Figueres/Berlin Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
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Preface
One of the major challenges for post-genomic biology is to understand how genes, proteins, and small molecules interact to form cellular systems. It has been recognized that a complicated living organism cannot be completely understood by merely analyzing individual components, and that interactions between these components or biomolecular networks in terms of structures and dynamics are ultimately responsible for an organism’s form and functions. To elucidate the essential principles or fundamental mechanisms in cellular systems, study of structures and dynamics of biomolecular networks in cells is increasingly attracting much attention from biology, mathematics, and engineering communities. In particular, there are many complicated but interesting phenomena generated from the biomole
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