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Mol Diagn Ther 2009; 13 (6): 407-412 1177-1062/09/0006-0407/$49.95/0

ª 2009 Adis Data Information BV. All rights reserved.

From the Literature Case ReportsContents 1. Antineoplastics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 407 2. Antivirals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 408 3. Cardiovascular Therapies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 409 4. Endocrine Disorder Therapies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 409 5. Immunosuppressants. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 410 6. Neurologic and Psychiatric Therapies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 410 7. Osteoporosis Therapies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 411 8. Skin Disorder Therapies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 412

1. Antineoplastics Cyclophosphamide/Melphalan: Early-Onset Acute Lymphoblastic Leukemia in a Patient with Multiple Myeloma: Case Report

A 61-year-old woman with multiple myeloma developed acute lymphoblastic leukemia (ALL) with mixed-lineage leukemia gene (MLL) rearrangement after receiving cyclophosphamide and melphalan [durations of therapies not stated]. The woman presented in January 2007. She was diagnosed with multiple myeloma; she had a normal karyotype (46,XX[20/20]). In July 2007, following 4 cycles of high-dose dexamethasone, her peripheral blood stem cells were mobilized and collected using cyclophosphamide 4 g/m2 and granulocyte colony-stimulating factor. In August 2007, she underwent autologous stem-cell transplantation with high-dose melphalan (200 mg/m2) as a conditioning regimen. She achieved partial remission. However, in July 2008, pancytopenia was detected. Her bone marrow had 94% blasts with the immunophenotype as B-cell lymphoblasts. Chromosomal abnormalities were evident: 46,XX,t(1;11)(p32–34;q23) [4/6]. Split signals of MLL gene were observed upon fluorescent in situ hybridization. She was diagnosed with B-ALL with MLL rearrangement. The woman was started on the JALSG

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