From the Literature

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From the Literature Case Reports-

Contents 1. Anesthetics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323 2. Anti-Infectives and Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323 3. Antineoplastics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 326 4. Cardiovascular Therapies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329 5. Estrogen Receptor Modulators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 330 6. Neurologic and Psychiatric Therapies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331 7. Other . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331

1. Anesthetics

2. Anti-Infectives and Vaccines

Suxamethonium Chloride: Prolonged Neuromuscular Blockade: Case Report

Ethambutol: Optic Neuropathy in a Patient with Autosomal Dominant Optic Atrophy: Case Report

A 48-year-old woman with known butyrylcholinesterase deficiency experienced prolonged neuromuscular blockade after inadvertent administration of suxamethonium chloride [succinylcholine chloride]. The woman was scheduled to undergo laparoscopic cholecystectomy for cholelithiasis. Following anesthesia induction with fentanyl and propofol, she received suxamethonium 100 mg (0.9 mg/kg) unintentionally. During the subsequent 90-minute surgical procedure, she received maintenance anesthesia with fentanyl, morphine, and propofol. Her subsequent recovery of neuromuscular function took more than 7 hours, with the first muscle twitch seen 87 minutes after administration of suxamethonium. Her plasma cholinesterase concentration was found to be 2520 U/L, with a dibucaine number of 8 – results indicative of a homozygous atypical variant; subsequent genetic sequencing identified homozygous A- and K- variants. Panhuizen IF, Snoeck MMJ, Levano S, et al. Prolonged neuromuscular blockade following succinylcholine administration to a patient with a reduced butyrylcholinesterase activity. Case Report Med 2010; 2010: 472389

A 32-year-old man, who had autosomal dominant optic atrophy, developed optic neuropathy during treatment with ethambutol for pulmonary tuberculos