Frontiers in Cancer Research Evolutionary Foundations, Revolutionary
This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diver
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Frontiers in Cancer Research Evolutionary Foundations, Revolutionary Directions
Frontiers in Cancer Research
Carlo C. Maley • Mel Greaves Editors
Frontiers in Cancer Research Evolutionary Foundations, Revolutionary Directions
Editors Carlo C. Maley Biodesign Institute, School of Life Sciences Arizona State University Tempe, AZ, USA
Mel Greaves Division of Molecular Pathology The Institute of Cancer Research London, UK
ISBN 978-1-4939-6458-1 ISBN 978-1-4939-6460-4 DOI 10.1007/978-1-4939-6460-4
(eBook)
Library of Congress Control Number: 2016949459 © Springer-Verlag New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
This book is dedicated by Carlo C. Maley to Athena Aktipis, whose vision, foresight, and wisdom improved this book (and his life) immeasurably
Preface
This book provides authoritative reviews of the current state of knowledge at the boundaries of cancer research with a focus on the evolutionary biology and ecology of cancer. These are the theoretical foundations of cancer biology. One of the unique features of this book is its emphasis on the open questions. Traditional textbooks focus on what is known, but science is focused on the unknown and the process of discovery. In other words, science is focused on the open questions. This has recently been recognized by the US National Cancer Institute, which initiated a research funding program around “provocative questions” in cancer research. In fact, a number of the questions addressed in this book have been chosen by the provocative question initiative for funding. The target audience for this book is scientists and people who want to understand the current limits of our knowledge about cancer. As such, we have asked the authors of the chapters to think hard about what are the most important open questions and provide their expert advice about
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