Frontotemporal dementia patients exhibit deficits in predictive saccades
- PDF / 1,300,353 Bytes
- 13 Pages / 595.276 x 790.866 pts Page_size
- 61 Downloads / 162 Views
Frontotemporal dementia patients exhibit deficits in predictive saccades Nicolas Deravet 1,2 & Jean-Jacques Orban de Xivry 3,4 & Adrian Ivanoiu 2,5 & Jean-Christophe Bier 6 & Kurt Segers 7 & Demet Yüksel 2,8 & Philippe Lefèvre 1,2 Received: 31 January 2020 / Revised: 2 September 2020 / Accepted: 10 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Prediction and time estimation are all but required for motor function in everyday life. In the context of eye movements, for instance, they allow predictive saccades and eye re-acceleration in anticipation of a target re-appearance. While the neural pathways involved are not fully understood, it is known that the frontal lobe plays an important role. As such, neurological disorders that affect it, such as frontotemporal (FTD) dementia, are likely to induce deficits in such movements. In this work, we study the performances of frontotemporal dementia patients in an oculomotor task designed to elicit predictive saccades at different rates, and compare them to young and older adults. Clear deficits in the production of predictive saccades were found in patients, in particular when the time between saccades was short (~500 ms). Furthermore, one asymptomatic C9ORF72 mutation bearer showed patterns of oculomotor behavior similar to FTD patients. He exhibited FTD symptoms within 3 years post-measure, suggesting that an impairment of oculomotor function could be an early clinical sign. Taken together, these results argue in favor of a role of the frontal lobe in predictive movements timing over short timescales, and suggest that predictive saccades in FTD patients warrant further investigation to fully assess their potential as a diagnostic aid. Keywords Saccade . Prediction . Time processing . FTD . Predictive saccade . Timing . Frontotemporal dementia . C9ORF72 . Eye movements
1 Introduction Frontotemporal Dementia (FTD) is an umbrella clinical term that designates a heterogeneous and complex group of neurodegenerative disorders (Bang et al. 2015; Bigio 2013; Laforce
2013), typically encompassing two broad categories according to the clinical presentation: behavioral variant FTD (bvFTD; Laforce 2013; Rascovsky et al. 2011) presenting with a frontal syndrome, and primary progressive aphasia (PPA) presenting with a language impairment, itself divided
Action Editor: Jeffrey Schall Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10827-020-00765-2) contains supplementary material, which is available to authorized users. * Philippe Lefèvre [email protected] 1
2
3
Institute of Information and Communication Technologies, Electronics, and Applied Mathematics, Université catholique de Louvain, Louvain-La-Neuve, Belgium Institute of Neuroscience, Université catholique de Louvain, Louvain-La-Neuve, Belgium Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, Katholieke Universiteit Leuven, Leuven, Belgium
4
Leuven Brain Institute, Katholieke Unive
Data Loading...
