Alzheimer's Disease and Frontotemporal Dementia Methods and Protocol
Alzheimer’s disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems that make us who we are. Major breakthroughs in recent
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
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Alzheimer’s Disease and Frontotemporal Dementia Methods and Protocols
Edited by
Erik D. Roberson Center for Neurodegeneration and Experimental Therapeutics, Departments of Neurology and Neurobiology, University of Alabama at Birmingham, AL, USA
Editor Erik D. Roberson, M.D., Ph.D. Center for Neurodegeneration and Experimental Therapeutics Departments of Neurology and Neurobiology University of Alabama at Birmingham, AL USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-743-3 e-ISBN 978-1-60761-744-0 DOI 10.1007/978-1-60761-744-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010938365 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Alzheimer’s disease (AD) is the most common neurodegenerative disorder and one of the most feared diseases due to the manner in which it robs its victims of their memories. Frontotemporal dementia (FTD) is perhaps somewhat less well known among the public, but it is also a prominent cause of dementia that produces devastating changes in personality and a decline in interpersonal interactions. The two conditions are often considered siblings, for while they are distinct disorders targeting different brain regions and producing unique clinical symptoms, there is some overlap in their molecular neuropathology (such as the presence of inclusions containing the microtubule-associated protein tau) and genetic risk factors (such as apolipoprotein E). Both conditions were originally described around the turn of the last century but languished without significant research effort for decades. In the 1980s, breakthroughs in p
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