Functional connectivity changes of nucleus Accumbens Shell portion in left mesial temporal lobe epilepsy patients
- PDF / 452,592 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 7 Downloads / 217 Views
ORIGINAL RESEARCH
Functional connectivity changes of nucleus Accumbens Shell portion in left mesial temporal lobe epilepsy patients Ru Yang 1,2
&
Xixi Zhao 3 & Jun Liu 2 & Xufeng Yao 4 & Feng Hou 2 & Yikai Xu 3 & Qianjin Feng 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Growing evidence has supported that the nucleus accumbens (NAc), especially its shell portion, has been involved in epileptogenesis. However, relevant studies on vivo human brain are quite limited. In this study, we investigated left mesial temporal lobe epilepsy (MTLE) related function connectivity (FC) changes of NAc subregions using resting-state functional magnetic resonance imaging. We calculated functional connectivity from two NAc subregions to both whole brain and 16 related targets. Two-sample t-test (Alphasim multiple comparisons corrected) was performed to identify the effect of the disease on each seed’s whole brain network. Repeated-measures ANOVA and Post hoc pairwise t test (Bonferroni corrections) were performed to visualize the seed to target FC group differences in each subdivision. In whole brain FC networks, neither the left or right core show different FC changes. The left shell showed decreased FC with a cluster located around the right inferior frontal gyrus. The right shell portion showed increased FC with a cluster located around the left inferior temporal gyrus. The seed to targets results showed that the left shell of LTLE group exhibited lower FC with left posterior-parahippocampal gyrus and right caudate, putamen, thalamus, paracingulate gyrus but higher FC with right subcallosal cortex. The right core of LTLE group exhibited higher FC with right frontal pole and the right shell exhibited lower FC with left thalamus and left anterior-parahippocampal gyrus. This is the first study to investigate the functional connectivity changes of NAc subdivisions of epilepsy in vivo human brain. Our results showed that the left MTLE related FC changes on NAc are mainly on shell portion rather than core. The decrease FC between the left shell and right frontal area and the decrease FC between the right shell and left temporal area suggested they serve vital roles for MTLE. Keywords Nucleus accumbens . Mesial temporal lobe epilepsy . Functional connectivity . Resting-state fMRI
Introduction The nucleus accumbens (NAc) of the human brain is an integral and specialized part of the ventral striatum (Heimer et al. 1991) and is located ventral and slightly medial to the head of
the caudate nucleus. Studies have shown that the NAc plays an important role in obtaining motivationally relevant goals by promoting likelihood, efficiency and vigor of behaviors intended goals (Floresco 2015). Abnormalities within this nucleus have been proposed to underlie numerous psychiatric
Ru Yang and Xixi Zhao contributed equally to this work. * Yikai Xu [email protected] * Qianjin Feng [email protected]
Feng Hou [email protected] 1
Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomed
Data Loading...
