Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery
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Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery Philipp Groene1 · Sophia R. Sappel1 · Thomas Saller1 · Tobias Nitschke1 · Paula A. Sa3 · Alexander Paulus2 · Daniel Chappell1,4 · Simon T. Schäfer1 Accepted: 1 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Tranexamic acid (TXA) can reduce blood loss and transfusion rates in orthopaedic surgery. In this regard, a new viscoelastometric test (TPA-test, ClotPro), enables the monitoring of TXA effects. This prospective observational study evaluated and correlated TXA plasma concentrations (cTXA) following intravenous and oral administration in patients undergoing elective orthopaedic surgery with lysis variables of TPA-test. Blood samples of 42 patients were evaluated before TXA application and 2, 6, 12, 24 and 48 h afterwards. TPA-test was used to determine lysis time (LT) as well as maximum lysis (ML) and cTXA was measured using Ultra-High-Performance-Liquid-Chromatography/Mass-Spectrometry. Data are presented as median (min–max). LTTPA-test and MLTPA-test correlated with cTXA (r = 0.9456/r = 0.5362; p
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