Loxoprofen/tranexamic acid
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Fixed drug eruption and aseptic meningitis: case report A 42-year-old woman developed fixed drug eruption during treatment with tranexamic acid for bacterial pharyngitis. Additionally, she developed aseptic meningitis during treatment with loxoprofen for the bacterial pharyngitis. The woman was admitted in the ICU with moderate disorientation, fever, and multiple, well-circumscribed, round, pigmented patches surrounded with erythema on her neck, back and pre-cordia. Her symptoms appeared 2 days prior to presentation following the administration of tranexamic acid and loxoprofen [routes and dosages not stated] along with amoxicillin for bacterial pharyngitis due to cold. Cerebrospinal fluid examination revealed aseptic meningitis. The woman received prednisolone, and all the three drugs were discontinued following which her skin lesions, disorientation and fever immediately regressed. She reported that similar eruptions had appeared 2 years previously, when she received tranexamic acid for tonsillitis. After 10 months, the woman took loxoprofen for a headache, and the following day, she developed aseptic meningitis. Following the discontinuation of loxoprofen, her symptoms disappeared immediately. A drug lymphocyte transformation test was positive for tranexamic acid, indicating that her skin rash was a fixed drug eruption secondary to tranexamic acid. On the basis of the immune abnormality findings, her meningitis was diagnosed as loxoprofen-induced aseptic meningitis. Author comment: "Since the result of [lymphocyte transformation test] for tranexamic acid was positive, the skin rash was diagnosed as fixed drug eruption induced by tranexamic acid. With respect to meningitis, drug‐induced aseptic meningitis by loxoprofen was diagnosed". Kawaguchi K, et al. Tranexamic acid-induced fixed drug eruption confirmed by the drug lymphocyte transformation test. Clinical Case Reports 7: 2074-2075, No. 11, 26 Sep 2019. Available from: URL: http://doi.org/10.1002/ccr3.2442 803442049 Japan
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Reactions 4 Jan 2020 No. 1785
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